Objectif There is a high demand for the development of new drug delivery strategies to combat major diseases in our society, particularly cancer. Current treatments are based on high efficacy drugs, however their non-selective uptake by both normal and tumor cells as well as the development of multidrug resistance (MDR), constitute major hurdles. Resistance is also associated with the use of nucleoside analogues as anticancer drugs in vivo. Photodynamic therapy (PDT), aims at selectively killing neoplastic lesions by the combined action of a photosensitizer and visible light. Passive targeting, involving enhanced permeability and retention effect, allows the accumulation of drugs on tumor sites, and concomitant active targeting with suitable functionalities, constitute properties currently associated with polymeric delivery systems. Cyclodextrins (CDs) are biocompatible and biodegradable oligosaccharide nanocages, known to improve the solubility, stability and bioavailability of drugs. Scattered literature reports incidents that CDs may constitute potential means to overcome certain forms of MDR, or to effectively deliver photosensitizing anticancer drugs preserving their photodynamic properties. This network, highly specialized in CD chemistry, photochemistry, in vitro drug evaluation and in vivo applications, proposes to synthesize diverse families of new CD derivatives to build a platform of CD-based drug delivery nanosystems with a variety of architectures. These new generation nanocarriers, encompassing many cavities in a nm-sized vehicle, will possess high drug loading capacity, improved permeability and retention effect, enhanced targeting and complete biocompatibility. Their mode of action will be assessed in vitro and in vivo. These goals will be achieved via a strong training program of ESRs and ERs in a highly collaborating, multidisciplinary and application oriented program, with full participation of an SME partner, a leader in CD applications. Champ scientifique natural scienceschemical sciencesphysical chemistryphotochemistrymedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistance Mots‑clés Health sciences Natural sciences anticancer drugs cyclodextrins drug delivery nanocarriers nanomedicine photosensitizing drugs Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-ITN-2008 - Marie Curie Action: "Networks for Initial Training" Appel à propositions FP7-PEOPLE-ITN-2008 Voir d’autres projets de cet appel Régime de financement MC-ITN - Networks for Initial Training (ITN) Coordinateur "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" Contribution de l’UE € 411 432,00 Adresse END OF PATRIARCHOU GRIGORIOU E AND 27 NEAPOLEOS STREET 15341 Agia Paraskevi Grèce Voir sur la carte Région Αττική Aττική Βόρειος Τομέας Αθηνών Type d’activité Research Organisations Contact administratif Styliani Martaki (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (8) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSIDAD DE CASTILLA - LA MANCHA Espagne Contribution de l’UE € 324 040,00 Adresse CALLE ALTAGRACIA 50 13071 Ciudad Real Voir sur la carte Région Centro (ES) Castilla-La Mancha Ciudad Real Type d’activité Higher or Secondary Education Establishments Contact administratif Maria Llanos Carrion-Varela (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France Contribution de l’UE € 348 297,00 Adresse RUE MICHEL ANGE 3 75794 Paris Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Contact administratif Michèle Saumon (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée HASKOLI ISLANDS Islande Contribution de l’UE € 249 269,00 Adresse SAEMUNDARGOTU 2 101 Reykjavik Voir sur la carte Région Ísland Ísland Höfuðborgarsvæði Type d’activité Higher or Secondary Education Establishments Contact administratif Sigurdur J. Hafsteinsson (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITA DEGLI STUDI DI CATANIA Italie Contribution de l’UE € 299 649,00 Adresse PIAZZA UNIVERSITA 2 95131 Catania Voir sur la carte Région Isole Sicilia Catania Type d’activité Higher or Secondary Education Establishments Contact administratif Clara Pluchino (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée CONSIGLIO NAZIONALE DELLE RICERCHE Italie Contribution de l’UE € 211 603,00 Adresse PIAZZALE ALDO MORO 7 00185 Roma Voir sur la carte Région Centro (IT) Lazio Roma Type d’activité Research Organisations Contact administratif Giancarlo Seconi (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée GOETEBORGS UNIVERSITET Suède Contribution de l’UE € 218 583,00 Adresse VASAPARKEN 405 30 Goeteborg Voir sur la carte Région Södra Sverige Västsverige Västra Götalands län Type d’activité Higher or Secondary Education Establishments Contact administratif Ludde Edgren (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSIDAD DE ALMERIA Espagne Contribution de l’UE € 195 917,00 Adresse CARRETERA SACRAMENTO CANADA 04120 Almeria Voir sur la carte Région Sur Andalucía Almería Type d’activité Higher or Secondary Education Establishments Contact administratif Antonio Miguel Posadas Chinchilla (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée CYCLOLAB CIKLODEXTRIN KUTATO-FEJLESZTO KFT Hongrie Contribution de l’UE € 156 757,00 Adresse ILLATOS UT 7 1097 Budapest Voir sur la carte Région Közép-Magyarország Budapest Budapest Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Erzsebet Szilagyi (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée