Objective
Sunlight is one of the major genotoxic threats in our environment. A great deal of previous work has uncovered the molecular pathways involved in the induction of damage in DNA by the UVB and UVC components of sunlight, and how that damage is repaired. I n contrast, much less is known about the effects of UVA even though recent epidemiological studies show that exposure to UVA correlates with the development of skin cancer. The object of this project is to understand how the higher-order structure of the genome influences the way damage in DNA is induced by UVA irradiation, and how that damage is repaired. UVA induces DNA damage indirectly via cellular sensitizers to generate reactive oxygen species that have a short diffusional range; as a result, the da mage must lie close to the sensitizers. However, the molecular nature of these sensitizers remains unknown, and so the first goal of this project is to identify the intra-nuclear structures that contain the sensitizers by localizing DNA damage relative to known structures within nuclei. In vitro tests with fractionated nuclear extracts will help to identify these structures and to verify results obtained by imaging. The organization of the chromatin fibre is also known to influence repair; therefore, a s econd part of the project will involve an analysis on how that organization influences induction and repair. Finally, I will try to transfer results obtained with cell cultures to a skin culture model that has more relevance to human epidemiology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology skin cancer
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics chromosomes
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OXFORD
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.