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Bio-Orthogonal Chemo-Specific Ligation

Objective

The Post-genomic era calls for a deep understanding of protein structure and function. The elucidation of protein structures, localization, post-translation modifications, and protein-macromolecule interactions are important to establish their role in the biology of the cell. To establish their role and investigate the protein functions requires the integration of various complementary disciplines. Among all disciplines, chemistry is central in establishing new effective ways to manipulate a biological entity to understand cellular processes with molecular precision. For studying, analyzing and manipulating a macromolecule, the site-specific incorporation of reporter molecules, by virtue of ligation reactions, is a key factor. The BioChemLig research project presented herein describes novel approaches for the discovery of new bio-compatible and chemo-specific ligation reactions. The aim of this project is to develop new ligation processes with high efficiency, large scope of application, high chemoselectivity and high rates. Through a well established network, with demonstrated success (IBAAC Project: FP6-505020), we propose to focus our efforts in a highly combined and integrated training research action conducting research and using: unusual organic chemical functionalities for ligation, environmentally benign “on water” ligation reactions, specific 18F radiolabelled reagents, dendrimers conjugation methodologies, high-throughput screening for bond forming reactions, bio-chemo informatics platform for theoretical investigations, artificial metalo-enzymes for template-directed ligation, templated ligation reactions and HTS. This high quality integrated research should ultimately allow scientists to dissect cellular processes with molecular precision, speed up preparation of library of bioconjugates and deliver innovatives approaches to chemical biology.

Call for proposal

FP7-PEOPLE-ITN-2008
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

UNIVERSITE DE STRASBOURG
Address
Rue Blaise Pascal 4
67081 Strasbourg
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 667 996,71
Administrative Contact
Laurence Petin-Monteil (Ms.)

Participants (7)

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 579 589,08
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pier Paolo Palmieri (Dr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 396 892,27
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stewart Deakin (Mr.)
UNIVERSITAET BERN
Switzerland
EU contribution
€ 434 706,96
Address
Hochschulstrasse 6
3012 Bern
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jean-Louis Reymond (Prof.)
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 402 474,74
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
Frédéric Taran (Dr.)
KEMIJSKI INSTITUT
Slovenia
EU contribution
€ 227 216,18
Address
Hajdrihova 19
1000 Ljubljana
Activity type
Research Organisations
Administrative Contact
Maja Miric (Ms.)
UNIVERSITAT BASEL
Switzerland
EU contribution
€ 434 706,99
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Ward (Prof.)
caprotec bioanalytics GmbH
Germany
EU contribution
€ 178 504
Address
Volmerstrasse 5
12489 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Sefkow (Dr.)