Objective
The Heat shock Factor 1 (HSF-1) is a transcription factor that upon activation enters the nucleus and regulates the transcription of its target gene networks. In the nematode C. elegans, HSF-1 is critical for the regulation of a variety of fundamental biological functions including development and stress resistance. In addition, it mediates protection from toxic protein aggregation and longevity facilitated by reduction of the Insulin/IGF signaling pathway, functions that point to HSF-1 as a promising target for the development of neurodegeneration therapies. Despite its key regulatory importance and therapeutic potential, little is known about the gene netwroks regulated by HSF-1 and its co-factors. Here I propose a systematic study designed to explore the different aspects of HSF-1 roles in regulating longevity and countering toxic protein aggregation. First the timing in which HSF-1 regulates longevity and counter toxicity associated with the aggregation of the Alzheimer’s disease linked peptide, Aβ. Next, the relations with components of the Insulin/IGF signaling pathway and its target genes networks will be studied at the correct temporal pattern, followed by exploration of the molecular co-factors that interact with HSF-1 at the longevity assurance time window. The proposed study will shed light on the molecular mechanisms that prevent late onset neurodegenerative disorders to emerge early in life and will point to new avenues towards the development of novel neurodegeneration therapies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences biological sciences biochemistry biomolecules proteins
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IRG-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
91904 JERUSALEM
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.