Objective
One of the more important recent developments in clinical oncology has been the approval of antiangiogenic drugs for the treatment of various types of cancer. We have found that these drugs not only act locally to inhibit the formation of new blood vessel capillaries in tumors, but also systemically by targeting bone marrow-derived endothelial precursor cells (CEPs). It has been suggested that other bone marrow-derived cell (BMDC) types contribute to tumor angiogenesis and growth by either directly incorporating to the vessel lumen or by residing at preivascular site - promoting angiogenesis by unknown paracrine mechanisms. With respect to CEPs, there is an ongoing controversy about their relative contribution to tumor blood vessel formation, in large due to a number of studies which reported low or even no detectable incorporation of such cells to the lumen of tumor blood vessel capillaries. We have recently shown that there are circumstances, namely, after acute cytotoxic drug therapy using vascular disrupting agents, or chemotherapy drugs including pactliaxel, 5-flourouracil, and docetaxel, where levels of CEPs are acutely mobilized from the bone-marrow niche, and subsequently colonize the drug-treated tumors, where they can make a significant contribution to tumor re-growth. These observations suggest a new perspective as for the role of CEPs in tumor angiogenesis and growth. Here, we propose to evaluate the contribution of different BMDC types to tumor angiogenesis and growth, and their contribution to metastasis seeding after treatment with cytotoxic anti-cancer drug therapies. In addition we will identify the various host factors and cytokines which promote BMDC mobilization and tumor homing. A major emphasis will be placed on new treatment strategies that can inhibit the host bone-marrow responses which contribute to tumor cell repopulation and metastasis, and as such the results could reveal new combinatorial promising treatment modalities for cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IRG-2008
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
32000 Haifa
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.