Objective
Skeletal muscle is the largest insulin sensitive bodily organ and plays a major role in determining glucose homeostasis. Impaired insulin action in skeletal muscle is one of the earliest steps leading Type 2 diabetes mellitus (T2DM); a metabolic disease of increasing proportions. Current therapies to treat T2DM are insufficient and insight into the molecular cause of this disease is limited. Genetic and environmental factors play a role of the development of T2DM. Therefore, elucidation of the factors deter mining insulin sensitivity in skeletal muscle is of clinical importance to prevent and treat this disease. The major goal of this proposal is to elucidate the signaling pathways that regulate gene expression and insulin sensitivity on glucose metabolism in skeletal muscle from healthy and T2D people. During my doctoral studies I established muscle cultures for studies of insulin action, which I will use here to create an siRNA library to identify the role of specific protein kinases in insulin action. I will establish a 'diabetogene identification platform' based on gene expression profiling of skeletal muscle from well-characterized healthy and T2D people, as well as cultured muscle cells exposed to diverse metabolic components of the insulin resistant phenotype. I will also test whether serine phosphorylation of insulin signaling proteins impairs glucose metabolism and gene expression and whether pharmacological intervention prevents this event. I will leverage the expertise of Prof. Juleen Zierath and Dr Anna Krook to create novel reagents to ask physiologically relevant questions related to T2DM pathogenesis. This work will identify the link between constitutes of the insulin signaling pathway important for glucose metabolism and gene regulatory events. Moreover, we anticipate the results will identify the potential cause of insulin resistance and refine future T2DM treatment, which may one day impact European health care.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine endocrinology diabetes
- natural sciences biological sciences genetics RNA transcriptomes
- medical and health sciences basic medicine physiology homeostasis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.