Objective
Of great importance during embryonic development are secreted signaling molecules that control the differentiation, proliferation and patterning of forming tissues. Many of these signals act in a graded fashion to control cell behaviour in a concentration dependent manner. Sonic Hedgehog (Shh) is an example of such a signal that controls the generation of distinct neuronal subtypes in the neural tube. In response to Shh signalling, the ventral neural tube is divided into compartmentalised progenitor pools, e ach of which generates distinct neuronal progeny.
The boundaries between adjacent progenitor pools are delimited by sharp, patent changes in gene expression and the remarkable precision of these boundaries, together with the absence of intermixing of cells from adjacent pools, represents a critical step in the interpretation of graded Shh signalling. Here we aim to determine the mechanisms involved in this poorly understood process. We will focus on the role of cell-cell contact and differential cell adhesion. To this end, we will develop novel in vitro and in vivo approaches that combine state-of-the-art live imaging techniques and the latest chick transgenic technology. These will allow me to assay this process and provide powerful functional tests for candidate molecules and analysis of the epistatic relationships between the different molecular partners.
The project addresses questions that are at the forefront of research in developmental neurobiology, and more generally in biology. Knowledge of the mechanisms that confer precision to graded Shh signalling will advance our understanding of neural tube development and provide insight into general strategies that endow morphogen gradients with their extraordinary accuracy. Moreover, the basic science quest ions addressed in this project are of direct relevance to basic and therapeutically applicable stem cell research, in particular, the use of stem cells for analysing and treating neurodegenerative diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences cell biology cell signaling
- natural sciences biological sciences developmental biology
- medical and health sciences medical biotechnology cells technologies stem cells
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.