Objective
Allostasis, maintenance of stability through changes in an organism, is critically dependent on bi-directional communication between the neuroendocrine and immune systems. The immune and neuroendocrine systems share mediators and their receptors, and thus immune responses are reflected in neuroendocrine changes while, in turn, hormones and neuropeptides modulate immune functions. Disturbance of allostasis may have negative influence on the health status and welfare of humans/animals.
There is a large body of evidence that endogenous opioids produced by activated neuroendocrine system exert a variety of effects on immune performance. Opioids can affect the immune response either directly via opioid receptors localised on leukocytes, or indirectly via activati on of stress axis and sympathethic nervous system. Opioids and receptors have been identified in fish and their evolutionary relationship with mammalian factors and functions supports their essential role in neuroendocrine and immune responses. Understanding the physiological significance of this communication will allow developing efficient strategies for health control in aquaculture.
This project aims to undertake a joint effort within three laboratories to perform an interdisciplinary study into the rol e of opioids and opioid receptors in farmed fish. Joining forces of the expert knowledge in fish immunology (Wageningen), neuroendocrinology (Nijmegen), together with the inflammation model developed in Poland will guarantee optimal conditions. The different types of opioid receptors will be characterised and influence of opiates on innate immune response and on classical stress axis will be established. The project offers a unique training opportunity in advanced molecular and cellular techniques that will be of great benefit form my research career and for establishment a firm co-operation between three European Laboratories.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- agricultural sciences agriculture, forestry, and fisheries fisheries
- medical and health sciences health sciences inflammatory diseases
- medical and health sciences health sciences infectious diseases
- medical and health sciences basic medicine immunology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
9101 WAGENINGEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.