Objective Allostasis, maintenance of stability through changes in an organism, is critically dependent on bi-directional communication between the neuroendocrine and immune systems. The immune and neuroendocrine systems share mediators and their receptors, and thus immune responses are reflected in neuroendocrine changes while, in turn, hormones and neuropeptides modulate immune functions. Disturbance of allostasis may have negative influence on the health status and welfare of humans/animals. There is a large body of evidence that endogenous opioids produced by activated neuroendocrine system exert a variety of effects on immune performance. Opioids can affect the immune response either directly via opioid receptors localised on leukocytes, or indirectly via activati on of stress axis and sympathethic nervous system. Opioids and receptors have been identified in fish and their evolutionary relationship with mammalian factors and functions supports their essential role in neuroendocrine and immune responses. Understanding the physiological significance of this communication will allow developing efficient strategies for health control in aquaculture. This project aims to undertake a joint effort within three laboratories to perform an interdisciplinary study into the rol e of opioids and opioid receptors in farmed fish. Joining forces of the expert knowledge in fish immunology (Wageningen), neuroendocrinology (Nijmegen), together with the inflammation model developed in Poland will guarantee optimal conditions. The different types of opioid receptors will be characterised and influence of opiates on innate immune response and on classical stress axis will be established. The project offers a unique training opportunity in advanced molecular and cellular techniques that will be of great benefit form my research career and for establishment a firm co-operation between three European Laboratories. Fields of science natural sciencesbiological sciencesneurobiologyagricultural sciencesagriculture, forestry, and fisheriesfisheriesmedical and health scienceshealth sciencesinflammatory diseasesmedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesbasic medicineimmunology Keywords apoptosis chemokine cytokine fish inflammation morphine receptor Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Topic(s) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Call for proposal FP6-2004-MOBILITY-5 See other projects for this call Funding Scheme EIF - Marie Curie actions-Intra-European Fellowships Coordinator WAGENINGEN UNIVERSITY Address Costerweg 50 9101 Wageningen Netherlands See on map Links Website Opens in new window EU contribution € 0,00
