Objective
Recent evidence suggests that only a subset of tumour cells is capable of giving rise to a new tumour. These tumour stem cells are functionally similar to stem cells in adult tissues and are identified in tumours of hematopoietic system, brain and mammary gland. Whether transformation of adult stem cells into tumour stem cells is the event leading to the disease is not clear. Alternatively, tumours could arise from the population of committed progenitors, which have de novo acquired self-renewal properties.
The purpose of this project is to investigate the contribution of stem cell and progenitor populations into carcinogenesis in skin and mammary gland. The questions to be answered:
1. Does oncogene activation alter the amount and proliferation properties of stem cells and/or progenitors?
2. Are stem cells involved in carcinogenesis in skin and mammary gland?
3. Are there stem cell-like cells in skin tumours?
The activity of hedgehog (Hh) pathway has been shown to be required for growth of a variety of tumours including basal cell carcinoma. Here the tetracycline-controlled conditional expression of the main effector of the Hh signalling pathway - Glil in mouse skin and mammary gland is used as a model system. The dynamics of changes in the cellular composition after Gli 1 induction are monitored and the proliferative potential of different cell subpopulations is evaluated.
A cross of inducible Gli1 mice and ubiquitously lacz expressing mice will be created to follow the progeny of stem cells. The potential tumourigenecity of sorted and engrafted populations of stem and progenitor cells is evaluated following Gli1 activation. Finally identification of tumour stem cells from tumours induced in Gli1 expressing mice will be attempted by cell culture methods. The outcome of this project will contribute to our understanding of cancer development in general and have implications to the therapeutic strategies of skin and mammary cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine oncology skin cancer basal cells
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.