Objective
Functional interpretation of the sequences is a prerequisite to the medical and economic utilization of the genetic databases; it is a priority area in the European Union. Understanding the function of riboswitches (mRNAs that regulate gene expression) is part of deciphering the genetic code. The applicant, Dr. Szabolcs Osváth, has expertise in several biophysical techniques, molecular biology, and thermodynamic modelling. He is capable to learn new methods and introduce them at his home institution. After he learned molecular biology in the lab of Prof. Martin Gruebele, he returned to Hungary and set up a laboratory for recombinant protein expression at the Semmelweis University. In Vienna the applicant will work in the emerging new field of studying riboswitches. His work will provide the basis of an envisaged collaboration between three labs of the Max F. Perutz Laboratories.
The applicant will study the stability, folding and ligand binding of the flavin mononucleotide dependent riboswitch. This riboswitch is suitable for spectroscopic studies using fluorescence correlation methods on small sample volumes. The aim is to determine thermodynamic parameters that can serve as input for computer modelling. The training will enable the applicant to undertake independent research on riboswitches. Since there is a lot of excitement about their possible medical use, the topic fits particularly well to the applicant's home university, where focus is on medical training and research.
The applicant's home department h as a strong interest in macromolecular dynamics and welcomes this new line of research. After joining the European Union in 2004, there was a large increase in the number of the students, who wish to study in German, and more German speaking teachers would be needed. In Vienna the applicant will learn German intensively, to be able to teach biophysics in German, what will be very useful after returning to Hungary.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences educational sciences didactics
- natural sciences computer and information sciences databases
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biophysics
- natural sciences biological sciences molecular biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.