Objective
Programmed cell death and inflammation are two closely related, fundamental processes in eukaryotic cells. Defects in either process or in the signalling cascades leading to these processes have severe consequences including major diseases like cancer and au toimmune diseases. Here we want to investigate the biochemical and structural properties of human proteins involved in PCD and inflammation by state of the art high throughput means.
The key to any biochemical and structural analysis of a protein is the ability to express and purify the protein of interest. Methods adopted from structural genomics initiatives provide today the opportunity to investigate many constructs of proteins in parallel or entire protein families in a high throughput manner. As investigated system we have chosen the RIP kinase family and complexes, in which RIP kinases play a role. Recent results show that the RIP kinase are involved in key steps in PCD and inflammation and are therefore important regulatory proteins. They seem to have also higher affinities to several important small molecule kinase inhibitors, than the actual targets, e.g. Abelson or p38 kinase.
RIP kinases are known to form complexes using their N- or C-terminal protein-protein interaction domains to target the ki nase domains to their site of action. Furthermore, the heat shock protein 90 (HSP90) is believed to interact with the kinase domain of the RIP kinase family, similar to the cyclin in the cyclin dependent kinase super-family. Other targets enclose members of the Caterpiller superfamily of proteins. The Caterpiller proteins are multi-domain proteins with a highly homologous molecular architecture, comprising an N-terminal protein-protein interaction, followed by a NTP dependent oligomerisation domain, a C-term inal detection domain but are not well characterized. These multiprotein complexes serve as platform to activate e.g. RIP kinases or caspases, finally leading to cell death or inflammation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences clinical medicine oncology
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.