Dissecting the Immunological Interplay between Poverty Related Diseases and Helminth Infections: An African-European Research Initiative

Objective

Worm infections are receiving increased attention due to: the wide geographic overlap in occurrence between worms and HIV, TB and malaria; the large proportion of individuals (minimal estimates around 25%) co-infected with worms and HIV/TB/ malaria; the potential risk of increasing disease burden; the very limited understanding of the impact by worm infections on HIV-, TB- and malaria-specific immune responses and on their clinical outcome; the lack of established intervention guidelines for treatment of worm infections; and the scarce information on the impact by worm infections on vaccination and vaccine-induced immune responses. In order to address these complex and challenging scientific issues, IDEA project will focus its efforts on four primary objectives: a) the worm-induced modulation of the functional and molecular profile of HIV-, TB- and malaria-specific immune responses, b) the impact by worm co-infections on measures of disease activity of PRDs, c) the immunologic markers of worm-, HIV-, TB- and malaria-specific immune responses associated with better control of pathogen replication and disease, and d) the modulation by worm co-infections of vaccine-induced immune responses. To achieve these objectives, IDEA project has developed a global and innovative strategy which includes: a) the alliance between African and European leading scientists in the field of worms, HIV, TB and malaria, b) the multidisciplinary expertise involving immunologists, parasitologists, epidemiologists, clinicians, and experts in vaccines, c) cutting edge immunology and the most innovative technologies to profile immune response, d) the access to large cohort studies bringing a number of centres working on worms and PRDs in Africa together, and e) the access to experimental HIV, TB and malaria vaccine candidates under clinical development in Africa.

Field of science

/medical and health sciences/health sciences/public and environmental health/epidemics prevention/immunisation
/medical and health sciences/health sciences/infectious disease/RNA virus/hiv
/medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines
/medical and health sciences/health sciences/infectious disease/malaria

Funding Scheme

CP-IP-SICA - Large-scale integrating project for specific cooperation actions dedicated to international cooperation partner countries(SICA)

Coordinator

CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS

Address

Rue Du Bugnon 21
1011 Lausanne
Switzerland

Activity type

Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)

EU contribution

€ 1 623 442

Objective

Field of science

Programme(s)

Topic(s)

Call for proposal

Funding Scheme

Coordinator

Participants (22)

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