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Dissecting the Immunological Interplay between Poverty Related Diseases and Helminth Infections: An African-European Research Initiative

Objective

Worm infections are receiving increased attention due to: the wide geographic overlap in occurrence between worms and HIV, TB and malaria; the large proportion of individuals (minimal estimates around 25%) co-infected with worms and HIV/TB/ malaria; the potential risk of increasing disease burden; the very limited understanding of the impact by worm infections on HIV-, TB- and malaria-specific immune responses and on their clinical outcome; the lack of established intervention guidelines for treatment of worm infections; and the scarce information on the impact by worm infections on vaccination and vaccine-induced immune responses. In order to address these complex and challenging scientific issues, IDEA project will focus its efforts on four primary objectives: a) the worm-induced modulation of the functional and molecular profile of HIV-, TB- and malaria-specific immune responses, b) the impact by worm co-infections on measures of disease activity of PRDs, c) the immunologic markers of worm-, HIV-, TB- and malaria-specific immune responses associated with better control of pathogen replication and disease, and d) the modulation by worm co-infections of vaccine-induced immune responses. To achieve these objectives, IDEA project has developed a global and innovative strategy which includes: a) the alliance between African and European leading scientists in the field of worms, HIV, TB and malaria, b) the multidisciplinary expertise involving immunologists, parasitologists, epidemiologists, clinicians, and experts in vaccines, c) cutting edge immunology and the most innovative technologies to profile immune response, d) the access to large cohort studies bringing a number of centres working on worms and PRDs in Africa together, and e) the access to experimental HIV, TB and malaria vaccine candidates under clinical development in Africa.

Field of science

  • /medical and health sciences/health sciences/infectious disease/malaria

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-IP-SICA - Large-scale integrating project for specific cooperation actions dedicated to international cooperation partner countries(SICA)

Coordinator

CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Address
Rue Du Bugnon 21
1011 Lausanne
Switzerland
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
EU contribution
€ 1 623 442
Administrative Contact
Giuseppe Pantaleo (Prof.)

Participants (22)

EUROPEAN VACCINE INITIATIVE EWIV
Germany
EU contribution
€ 250 000
Address
Vossstrasse 2 Geb 4040
69115 Heidelberg
Activity type
Research Organisations
Administrative Contact
Sten Larsen (Dr.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 1 042 910
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Hm Thm Ottenhoff (Prof.)
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom
EU contribution
€ 774 369,74
Address
Keppel Street
WC1E 7HT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jana Sabinovska (Ms.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 804 100
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Adrian Hill (Prof.)
SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT
Switzerland
EU contribution
€ 840 453,74
Address
Socinstrasse 57
CH-4002 Basel
Activity type
Research Organisations
Administrative Contact
Marcel Tanner (Prof.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 490 000
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter G Kremsner (Prof.)
KENYA MEDICAL RESEARCH INSTITUTE
Kenya
EU contribution
€ 213 700
Address
Off Mbagathi Way
00200 Nairobi
Activity type
Research Organisations
Administrative Contact
Simon Brooker (Dr.)
MEDICAL RESEARCH COUNCIL
United Kingdom
EU contribution
€ 1 449 987
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Administrative Contact
Josephine Magoba-Makuyi (Ms.)
Agence nationale de recherches sur le sida et les hépatites virales
France
EU contribution
€ 3 600
Address
Rue De Tolbiac 101
75013 Paris
Activity type
Research Organisations
Administrative Contact
Véronique Rieux (Dr.)
ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO
Italy
EU contribution
€ 333 972,94
Address
Via Portuense, 292
00149 Roma
Activity type
Research Organisations
Administrative Contact
Ramona Iacovino (Dr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 247 199,70
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Didier Lemoine (Mr.)
College of Medicine, University of Ibadan
Nigeria
EU contribution
€ 300 780
Address
Queen Elisabeth Ii Road U.c.h.
200001 Ibadan
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Geroge Ademowo (Prof.)
EUROVACC FOUNDATION
Switzerland
EU contribution
€ 27 400
Address
Place Saint-francois 1 Etude Kellerhals Carrard
1003 Lausanne
Activity type
Other
Administrative Contact
Song Ding (Ms.)
IFAKARA HEALTH INSTITUTE TRUST
Tanzania
EU contribution
€ 205 400
Address
Kiko Avenue Off Old Bagamoyo Road Plot 463
Dar Es Salaam
Activity type
Research Organisations
Administrative Contact
Barnabas Lugendo (Dr.)
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 294 800
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
William Anderson Paxton (Dr.)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 106 440
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Hoelscher (Dr.)
NATIONAL INSTITUTE FOR MEDICAL RESEARCH
Tanzania
EU contribution
€ 63 400
Address
Sokoine Luthuli Drive Ocean Road
255 Dar Es Salaam
Activity type
Research Organisations
Administrative Contact
Julius J. Massaga (Ms.)
Fondation international de l'Hopital de Dr. Albert Schweitzer de LAMBARENE

Participation ended

Gabon
EU contribution
€ 218 588,19
Address
Hopital Albert Schweitzer Na
13901 Lambarene
Activity type
Other
Administrative Contact
Saadou Issifou (Dr.)
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 119 480
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nicola Harris (Prof.)
MALARIA CONSORTIUM LBG

Participation ended

United Kingdom
Address
Leonard Street 56-64
EC2A 4LT London
Activity type
Other
Administrative Contact
Peter Newton (Mr.)
VACCINE AND GENE THERAPY INSTITUTE OF FLORIDA CORP.
United States
EU contribution
€ 497 940
Address
Sw Village Parkway - 3Rd Floor 11350
34987 Port St Lucie Florida
Activity type
Research Organisations
Administrative Contact
Thomas Mitchell (Ms.)
Centre de Recherches Medicales de Lambaréné
Gabon
EU contribution
€ 392 036,69
Address
Na
118 Lambaréné
Activity type
Research Organisations
Administrative Contact
Olouyomi Scherif Adegnika (Mr.)