Objective
Worm infections are receiving increased attention due to: the wide geographic overlap in occurrence between worms and HIV, TB and malaria; the large proportion of individuals (minimal estimates around 25%) co-infected with worms and HIV/TB/ malaria; the potential risk of increasing disease burden; the very limited understanding of the impact by worm infections on HIV-, TB- and malaria-specific immune responses and on their clinical outcome; the lack of established intervention guidelines for treatment of worm infections; and the scarce information on the impact by worm infections on vaccination and vaccine-induced immune responses. In order to address these complex and challenging scientific issues, IDEA project will focus its efforts on four primary objectives: a) the worm-induced modulation of the functional and molecular profile of HIV-, TB- and malaria-specific immune responses, b) the impact by worm co-infections on measures of disease activity of PRDs, c) the immunologic markers of worm-, HIV-, TB- and malaria-specific immune responses associated with better control of pathogen replication and disease, and d) the modulation by worm co-infections of vaccine-induced immune responses. To achieve these objectives, IDEA project has developed a global and innovative strategy which includes: a) the alliance between African and European leading scientists in the field of worms, HIV, TB and malaria, b) the multidisciplinary expertise involving immunologists, parasitologists, epidemiologists, clinicians, and experts in vaccines, c) cutting edge immunology and the most innovative technologies to profile immune response, d) the access to large cohort studies bringing a number of centres working on worms and PRDs in Africa together, and e) the access to experimental HIV, TB and malaria vaccine candidates under clinical development in Africa.
Field of science
- /medical and health sciences/health sciences/public and environmental health/epidemics prevention/immunisation
- /medical and health sciences/health sciences/infectious disease/RNA virus/hiv
- /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines
- /medical and health sciences/health sciences/infectious disease/malaria
Call for proposal
FP7-HEALTH-2009-single-stage
See other projects for this call
Funding Scheme
CP-IP-SICA - Large-scale integrating project for specific cooperation actions dedicated to international cooperation partner countries(SICA)Coordinator
1011 Lausanne
Switzerland
Participants (22)
69115 Heidelberg
2333 ZA Leiden
WC1E 7HT London
OX1 2JD Oxford
CH-4002 Basel
72074 Tuebingen
00200 Nairobi
SN2 1FL Swindon
75013 Paris
00149 Roma
75654 Paris
200001 Ibadan
1003 Lausanne
Dar Es Salaam
1105AZ Amsterdam
80539 Muenchen
255 Dar Es Salaam
Participation ended
13901 Lambarene
1015 Lausanne
Participation ended
EC2A 4LT London
34987 Port St Lucie Florida
118 Lambaréné