Dissecting the Immunological Interplay between Poverty Related Diseases and Helminth Infections: An African-European Research Initiative

Objective

Worm infections are receiving increased attention due to: the wide geographic overlap in occurrence between worms and HIV, TB and malaria; the large proportion of individuals (minimal estimates around 25%) co-infected with worms and HIV/TB/ malaria; the potential risk of increasing disease burden; the very limited understanding of the impact by worm infections on HIV-, TB- and malaria-specific immune responses and on their clinical outcome; the lack of established intervention guidelines for treatment of worm infections; and the scarce information on the impact by worm infections on vaccination and vaccine-induced immune responses. In order to address these complex and challenging scientific issues, IDEA project will focus its efforts on four primary objectives: a) the worm-induced modulation of the functional and molecular profile of HIV-, TB- and malaria-specific immune responses, b) the impact by worm co-infections on measures of disease activity of PRDs, c) the immunologic markers of worm-, HIV-, TB- and malaria-specific immune responses associated with better control of pathogen replication and disease, and d) the modulation by worm co-infections of vaccine-induced immune responses. To achieve these objectives, IDEA project has developed a global and innovative strategy which includes: a) the alliance between African and European leading scientists in the field of worms, HIV, TB and malaria, b) the multidisciplinary expertise involving immunologists, parasitologists, epidemiologists, clinicians, and experts in vaccines, c) cutting edge immunology and the most innovative technologies to profile immune response, d) the access to large cohort studies bringing a number of centres working on worms and PRDs in Africa together, and e) the access to experimental HIV, TB and malaria vaccine candidates under clinical development in Africa.

Fields of science

• medical and health sciences › basic medicine › immunology
• medical and health sciences › health sciences › infectious diseases › RNA viruses › HIV
• medical and health sciences › health sciences › infectious diseases › malaria
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › vaccines

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Topic(s)

• HEALTH-2009-4.3.1-3 - Human immune responses to co-infections of poverty-related (HIV, malaria, TB) and neglected infectious diseases (SICA)

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-IP-SICA - Large-scale integrating project for specific cooperation actions dedicated to international cooperation partner countries(SICA)

Coordinator

CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS

Address

Rue Du Bugnon 21
1011 Lausanne
Switzerland

Activity type

Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)

EU contribution

€ 1 623 442

Administrative Contact

Giuseppe Pantaleo (Prof.)

Participants (22)

EUROPEAN VACCINE INITIATIVE EWIV

Germany

EU contribution

€ 250 000

Address

Vossstrasse 2 Geb 4040
69115 Heidelberg

Activity type

Research Organisations

Administrative Contact

Sten Larsen (Dr.)

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU contribution

€ 1 042 910

Address

Albinusdreef 2
2333 ZA Leiden

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Thomas Hm Thm Ottenhoff (Prof.)

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER

United Kingdom

EU contribution

€ 774 369,74

Address

Keppel Street
WC1E 7HT London

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Jana Sabinovska (Ms.)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU contribution

€ 804 100

Address

Wellington Square University Offices
OX1 2JD Oxford

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Adrian Hill (Prof.)

SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT

Switzerland

EU contribution

€ 840 453,74

Address

Socinstrasse 57
CH-4002 Basel

Activity type

Research Organisations

Administrative Contact

Marcel Tanner (Prof.)

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany

EU contribution

€ 490 000

Address

Geschwister-scholl-platz
72074 Tuebingen

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Peter G Kremsner (Prof.)

KENYA MEDICAL RESEARCH INSTITUTE

Kenya

EU contribution

€ 213 700

Address

Off Mbagathi Way
00200 Nairobi

Activity type

Research Organisations

Administrative Contact

Simon Brooker (Dr.)

MEDICAL RESEARCH COUNCIL

United Kingdom

EU contribution

€ 1 449 987

Address

North Star Avenue Polaris House
SN2 1FL Swindon

Activity type

Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)

Administrative Contact

Josephine Magoba-Makuyi (Ms.)

Agence nationale de recherches sur le sida et les hépatites virales

France

EU contribution

€ 3 600

Address

Rue De Tolbiac 101
75013 Paris

Activity type

Research Organisations

Administrative Contact

Véronique Rieux (Dr.)

ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO

Italy

EU contribution

€ 333 972,94

Address

Via Portuense, 292
00149 Roma

Activity type

Research Organisations

Administrative Contact

Ramona Iacovino (Dr.)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU contribution

€ 247 199,70

Address

Rue De Tolbiac 101
75654 Paris

Activity type

Research Organisations

Administrative Contact

Didier Lemoine (Mr.)

College of Medicine, University of Ibadan

Nigeria

EU contribution

€ 300 780

Address

Queen Elisabeth Ii Road U.c.h.
200001 Ibadan

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Geroge Ademowo (Prof.)

EUROVACC FOUNDATION

Switzerland

EU contribution

€ 27 400

Address

Place Saint-francois 1 Etude Kellerhals Carrard
1003 Lausanne

Activity type

Other

Administrative Contact

Song Ding (Ms.)

IFAKARA HEALTH INSTITUTE TRUST

Tanzania

EU contribution

€ 205 400

Address

Kiko Avenue Off Old Bagamoyo Road Plot 463
Dar Es Salaam

Activity type

Research Organisations

Administrative Contact

Barnabas Lugendo (Dr.)

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Netherlands

EU contribution

€ 294 800

Address

Meibergdreef 15
1105AZ Amsterdam

Activity type

Higher or Secondary Education Establishments

Administrative Contact

William Anderson Paxton (Dr.)

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU contribution

€ 106 440

Address

Geschwister Scholl Platz 1
80539 Muenchen

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Michael Hoelscher (Dr.)

NATIONAL INSTITUTE FOR MEDICAL RESEARCH

Tanzania

EU contribution

€ 63 400

Address

Sokoine Luthuli Drive Ocean Road
255 Dar Es Salaam

Activity type

Research Organisations

Administrative Contact

Julius J. Massaga (Ms.)

Fondation international de l'Hopital de Dr. Albert Schweitzer de LAMBARENE

Participation ended

Gabon

EU contribution

€ 218 588,19

Address

Hopital Albert Schweitzer Na
13901 Lambarene

Activity type

Other

Administrative Contact

Saadou Issifou (Dr.)

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Switzerland

EU contribution

€ 119 480

Address

Batiment Ce 3316 Station 1
1015 Lausanne

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Nicola Harris (Prof.)

MALARIA CONSORTIUM LBG

Participation ended

United Kingdom

Address

Leonard Street 56-64
EC2A 4LT London

Activity type

Other

Administrative Contact

Peter Newton (Mr.)

VACCINE AND GENE THERAPY INSTITUTE OF FLORIDA CORP.

United States

EU contribution

€ 497 940

Address

Sw Village Parkway - 3Rd Floor 11350
34987 Port St Lucie Florida

Activity type

Research Organisations

Administrative Contact

Thomas Mitchell (Ms.)

Centre de Recherches Medicales de Lambaréné

Gabon

EU contribution

€ 392 036,69

Address

Na
118 Lambaréné

Activity type

Research Organisations

Administrative Contact

Olouyomi Scherif Adegnika (Mr.)