Regenerating Bone defects using New biomedical Engineering approaches

Project Information

REBORNE

Grant agreement ID: 241879

Project closed

Start date 1 January 2010

End date 30 June 2015

Funded under

• Specific Programme "Cooperation": Health

Total cost € 15 472 075,44

EU contribution € 11 935 340,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Objective

Bone is among the most frequently transplanted tissue with about 1 million procedures annually in Europe. The worldwide market of bone replacement materials is currently estimated at 5 billion € with a 10% annual growth. Despite their considerable disadvantages, including the risk of disease transfer and immunologic rejection, limited supply of bone, costs and complications, allografts and autografts account for more than 80% of total graft volume. Significant growth opportunities exist for synthetic bone grafts in association with mesenchymal stem cells from autologous or allogenic sources as alternatives to biological bone grafts in orthopaedic and maxillofacial surgery. The objectives of REBORNE is to perform clinical trials using advanced biomaterials and cells triggering bone healing in patients. In order to reach this goal, five phase II clinical studies with 20 patients are proposed in 12 clinical centres spread in 8 European countries. Three orthopaedic trials concerning the treatment of long bone fractures and osteonecrosis of the femoral head in adults or children will be conducted using bioceramics, hydrogel for percuteneous injection and stem cells from autologous or allogenic sources. Clinical research will also concern maxillofacial surgery with bone augmentation prior to dental implants and the reconstruction of cleft palates in children. The safety and efficacy of the new therapies will be assessed clinically using X-rays, CT scans and MRI as well as histology of biopsies. These ambitious clinical targets will require research and development efforts from a large consortium of top world class laboratories, SMEs manufacturing biomaterials, GMP-cell producing facilities and surgeons in hospitals as well as the consideration of ethical and regulatory issues. It is expected that REBORNE will expand the competitiveness of Europe through the patenting of new CE-marked bioproducts in the field of regenerative medicine.

Fields of science

• medical and health sciences › medical biotechnology
• medical and health sciences › clinical medicine › orthopaedics

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Topic(s)

• HEALTH-2009-1.4-2 - Regeneration of tissue using bio-compatible materials and cells

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

• EU contribution: € 2 121 051,08
• Address: RUE DE TOLBIAC 101 ; 75654 Paris ; France
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Marianne Desmedt (Ms.)
• Total cost: No data

Participants (23)

ETABLISSEMENT FRANCAIS DU SANG

France

• EU contribution: € 1 439 351,40
• Address: AVENUE DU STADE DE FRANCE 20 ; 93210 La Plaine Saint Denis
• Region: Ile-de-France › Ile-de-France › Seine-Saint-Denis
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Laurent Beauverger (Mr.)
• Total cost: No data

BIOMATLANTE

France

• EU contribution: € 477 500,00
• Address: 5 RUE EDOUARD BELIN - ZA DES IV NATIONS ; 44360 Vigneux De Bretagne
• Region: Pays de la Loire › Pays de la Loire › Loire-Atlantique
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Isabelle Bocherel (Ms.)
• Total cost: No data

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

• EU contribution: € 224 994,00
• Address: RUE LEBLANC 25 ; 75015 PARIS 15
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Nathalie Rouas-Freiss (Dr.)
• Total cost: No data

FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO

Italy

• EU contribution: € 546 715,54
• Address: VIA FRANCESCO SFORZA 28 ; 20122 Milano
• Region: Nord-Ovest › Lombardia › Milano
• Activity type: Other
• Administrative Contact: Rosaria Giordano (Dr.)
• Total cost: No data

CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES

Participation ended

France

• EU contribution: € 99 892,17
• Address: Allee de l'Ile Gloriette 5 ; 44093 Nantes
• Region: Pays de la Loire › Pays de la Loire › Loire-Atlantique
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Annes Brethet (Ms.)
• Total cost: No data

ASSISTANCE PUBLIQUE HOPITAUX DE PARIS

France

• EU contribution: € 121 388,00
• Address: 55 BOULEVARD DIDEROT ; 75012 Paris
• Region: Ile-de-France › Ile-de-France › Val-de-Marne
• Activity type: Research Organisations
• Administrative Contact: Christophe Misse (Mr.)
• Total cost: No data

KITOZYME SA

Belgium

• EU contribution: € 300 160,00
• Address: RUE HAUTE CLAIRE PARC INDUSTRIEL 4 ; 4040 HERSTAL
• Region: Région wallonne › Prov. Liège › Arr. Liège
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Arnaud Hamers (Mr.)
• Total cost: No data

KUROS BIOSCIENCES BV

Netherlands

• EU contribution: € 401 600,00
• Address: PROFESSOR BRONKHORSTLAAN 10 G 48 ; 3723 MB Bilthoven
• Region: West-Nederland › Utrecht › Utrecht
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Florence De Groot (Dr.)
• Total cost: No data

UNIVERSITAT POLITECNICA DE CATALUNYA

Spain

• EU contribution: € 304 855,00
• Address: CALLE JORDI GIRONA 31 ; 08034 Barcelona
• Region: Este › Cataluña › Barcelona
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Maria Pau Ginebra (Prof.)
• Total cost: No data

UNIVERSIDAD AUTONOMA DE MADRID

Spain

• EU contribution: € 630 499,50
• Address: CALLE EINSTEIN 3 CIUDAD UNIV CANTOBLANCO RECTORADO ; 28049 Madrid
• Region: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Ana Amigo (Ms.)
• Total cost: No data

UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA

Italy

• EU contribution: € 803 109,26
• Address: VIA UNIVERSITA 4 ; 41121 Modena
• Region: Nord-Est › Emilia-Romagna › Modena
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Guiseppe Torelli (Prof.)
• Total cost: No data

UNIVERSITATEA DE MEDICINA SI FARMACIE VICTOR BABES TIMISOARA

Romania

• EU contribution: € 247 600,00
• Address: PIATA EFTIMIE MURGU 2A ; 300041 Timisoara
• Region: Macroregiunea Patru › Vest › Timiş
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Constanta Caplar
• Total cost: No data

CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS

France

• EU contribution: € 112 050,00
• Address: BOULEVARD TONELLE 2 ; 37044 Tours Cedex 9
• Region: Centre — Val de Loire › Centre — Val de Loire › Indre-et-Loire
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Philippe Rosset (Prof.)
• Total cost: No data

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany

• EU contribution: € 465 696,00
• Address: GESCHWISTER-SCHOLL-PLATZ ; 72074 Tuebingen
• Region: Baden-Württemberg › Tübingen › Tübingen, Landkreis
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Ingo Müller (Dr.)
• Total cost: No data

UNIVERSITAET ULM

Germany

• EU contribution: € 1 356 006,42
• Address: HELMHOLTZSTRASSE 16 ; 89081 Ulm
• Region: Baden-Württemberg › Tübingen › Ulm, Stadtkreis
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Frank Gleixner
• Total cost: No data

UNIVERSITA DEGLI STUDI DI VERONA

Italy

• EU contribution: € 481 199,62
• Address: VIA DELL ARTIGLIERE 8 ; 37129 Verona
• Region: Nord-Est › Veneto › Verona
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Giovanni Menegatti (Dr.)
• Total cost: No data

ALCIMED

France

• EU contribution: € 374 964,00
• Address: BOULEVARD DE MONTMORENCY 57 ; 75016 PARIS
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: David Bariau (Mr.)
• Total cost: No data

UNIVERSITETET I BERGEN

Norway

• EU contribution: € 409 868,75
• Address: MUSEPLASSEN 1 ; 5020 Bergen
• Region: Norge › Vestlandet › Vestland
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Inger Gjesdahl (Ms.)
• Total cost: No data

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands

• EU contribution: € 199 940,00
• Address: HEIDELBERGLAAN 100 ; 3584 CX Utrecht
• Region: West-Nederland › Utrecht › Utrecht
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: P.J.A. De Koning (Dr.)
• Total cost: No data

ISTITUTO ORTOPEDICO RIZZOLI

Italy

• EU contribution: € 363 180,00
• Address: VIA DI BARBIANO 1/10 ; 40136 Bologna
• Region: Nord-Est › Emilia-Romagna › Bologna
• Activity type: Research Organisations
• Administrative Contact: Andrea Rizzi (Dr.)
• Total cost: No data

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

• EU contribution: € 352 448,86
• Address: HOFGARTENSTRASSE 8 ; 80539 Munchen
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Activity type: Research Organisations
• Administrative Contact: Udo Schreiner (Mr.)
• Total cost: No data

AZIENDA OSPEDALIERA UNIVERSITARIA MEYER IRCCS

Italy

• EU contribution: € 88 800,00
• Address: VIALE PIERACCINI 24 ; 50139 Firenze
• Region: Centro (IT) › Toscana › Firenze
• Activity type: Research Organisations
• Administrative Contact: Franco Bambi (Dr.)
• Total cost: No data

UNIVERSITE DE LIEGE

Belgium

• EU contribution: € 12 470,40
• Address: PLACE DU 20 AOUT 7 ; 4000 Liege
• Region: Région wallonne › Prov. Liège › Arr. Liège
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Eric Rompen (Prof.)
• Total cost: No data