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The role of intestinal microflora in non-alcoholic fatty liver disease (NAFLD)

Objective

As worldwide metabolic disease pandemics rise relentlessly with their concomitant clinical complications such as non alcoholic fatty liver disease, FLORINASH proposes an innovative research concept to address the role of intestinal microfloral activity in the pathogenesis of NAFLD. Firstly, to discover novel metabolic markers for the differential diagnosis and prediction of patient risk. Secondly, to identify HITS as targets for new therapeutic or interventional approaches. The strength of the FLORINASH proposal lies in: i) The construction a large bank of tissues and biofluids (liver biopsies, urine, faeces, plasma) from NAFLD patients that have been phenotyped for obesity and for insulin resistance by hyperinsulinemic clamping. ii) The application of coupled bioinformatic and chemometric modelling of phenotypes via advanced system level omics metrics (utilizing metabolomic, proteomic, transcriptomic, and metagenomic platforms). iii) The mechanistic refinement and validation of human markers and target-HITS in complementary animal models and innovative humanized mice. iv) To validate currently available therapeutic candidates for the target-HITS and synthesize new chemical entities to interfere with these target-HITS. v) To elucidate and widely disseminate the systemic and long range metabolic impacts of intestinal microflora modulation on molecular pathways such as ER stress, lipogenic transcription factors and inflammatory agents. Hence, in addition to fundamental scientific advances that can be tranlated to individual healthcare scenarios, the European community will benefit more widely from numerous social, economical, clinical, scientific impacts resulting from the FLORINASH project.

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
EU contribution
€ 2 557 564,80
Address
RUE DE TOLBIAC 101
75654 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Administrative Contact
Muriel Bouas (Ms.)
Links
Total cost
No data

Participants (5)