Objectif
Major disorders of the Central Nervous System (CNS) affect one in three people in the developed world, often seriously disable the affected individual, and together account for the single largest burden on the healthcare systems of the EU. Most of these disorders act at the neuronal synapse, a cellular organelle comprising in the order of 2000 proteins. Pleiotropy, cross-talk between proteins and the complexity of the underlying signalling complexes pose a significant challenge to dissecting the molecular mechanisms of disease and to design efficient drugs. SynSys assembles leading European laboratories to provide the expertise and established research platforms that uniquely enable a systems-level analysis of synaptic signalling. The consortium features a closed loop from data integration and modelling, human genetics, physiology, proteomics and the application of engineered model systems to test model predictions. The main objectives of this project are to (i) provide a qualitative and quantitative description of the protein composition and the interactome of the mammalian glutamatergic synapse that integrates known human variation in these genes, (ii) to generate quantitative dynamic models describing the main functional features of the synaptic system, (iii) to reiterate on modeling by relating model predictions to synaptic function, (iv) to identify and validate, using appropriate model systems, human vulnerability genes that may form the basis of future therapies. Only a Systems level analysis can provide the means to describe synaptic transmission from molecule to function, its dynamics in relation to physiology and, brain function and brain disorders. As such, SynSys will establish a new platform for iterative molecular analysis of synapse function and dynamic modeling, with the perspective to generate a blueprint for discovery of novel pathways and targets that enable rational strategies to design therapies for human brain disease.
Champ scientifique
Appel à propositions
FP7-HEALTH-2009-two-stage
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Régime de financement
CP-IP - Large-scale integrating projectCoordinateur
1081 HV Amsterdam
Pays-Bas
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Participants (17)
Participation terminée
CB10 1SA SAFFRON WALDEN
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EH8 9YL Edinburgh
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80539 Munchen
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13125 Berlin
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69117 Heidelberg
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1165 Kobenhavn
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17177 Stockholm
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10117 Berlin
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75654 Paris
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9052 ZWIJNAARDE - GENT
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00014 Helsingin Yliopisto
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CB4 1GU Cambridge
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FK8 3RJ Gartmore
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754 50 Uppsala
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1008 BA AMSTERDAM
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CB22 3AT Cambridge
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Participation terminée
1081 HV Amsterdam
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