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Genomic variations underlying common behavior diseases and cognition trait in human populations

Objective

The subject of the proposal is the search and analysis of genomic variations underlying Alzheimer's disease (AD), alcoholism and schizophrenia – wide-spread diseases in human populations. Schizophrenia and alcoholism are common forms of behavior pathology and disability in adult life. AD is a most common form of dementia in human populations. Though the genomic variations presumably associated with AD, alcoholism and schizophrenia were described in preliminary studies for European populations, the significance of the putatively associated alleles, genetic background as well as the role of environmental factors is still poorly understood for them. Within the framework of this project we plan to extend the studies of genomic variations underlying these diseases by performing genome-wide association analysis in cohorts of patients and normal individuals from several ethnic populations of Europe and Russia.The genetic factors for cognition endophenotype will also be studied. Candidate regions, both newly found and reported previously for these diseases will be additionally analyzed by sequencing. Such large scale population studies combined with deep analysis of particular genes and genomic regions will allow us to reveal genetic reasons for susceptibility to these diseases. On the basis of this research we propose to contribute to development of a diagnostic instrument for the analysis of genetic risk factors for AD, alcoholism and schizophrenia. Comparison of several ethnic cohorts (different populations from Russia and Central/Western and Southern Europe) will also help to elucidate the influence of genetic background and environmental factors on the etiology of neuropsychiatric diseases. Consortium includes 6 groups from EU/AC and 7 groups from Russia. The participants are leading specialists in their fields and have joint publications on subjects related to this proposal.

Field of science

  • /medical and health sciences/basic medicine/pathology
  • /medical and health sciences/clinical medicine/psychiatry/schizophrenia
  • /medical and health sciences/basic medicine/neurology/alzheimer

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-FP-SICA - Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries(SICA)

Coordinator

Klinik Max Planck Institut für Psychiatrie
Address
Hofgartenstrasse 8
80539 Muenchen
Germany
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 618 000
Administrative Contact
Joachim Gerlach (Mr.)

Participants (11)

UNIVERSITAT BASEL
Switzerland
EU contribution
€ 783 000
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andreas Papassotiropoulos (Prof.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 378 000
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Koos (J.Th.N.) Lubbe (Mr.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 435 000
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Silke Blohm (Ms.)
ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT
Germany
EU contribution
€ 393 000
Address
Square J 5
68159 Mannheim
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Simone Fuchs (Ms.)
UNIVERSITATSKLINIKUM BONN
Germany
EU contribution
€ 393 000
Address
Venusberg-campus 1
53127 Bonn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beate Becker (Ms.)
ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY OF RUSSIAN ACADEMY
Russia
Address
Vavilov 32
119991 Moscow
Activity type
Research Organisations
Administrative Contact
Alexander Zasedatelev (Prof.)
Vavilov Institute of General Genetics - Russian Academy of Sciences
Russia
Address
Gubkin Str. 3
119991 Moscow
Activity type
Research Organisations
Administrative Contact
Irina Goldenkova-Pavlova (Prof.)
NATIONAL RESEARCH CENTER OF MENTAL HEALTH - RUSSIAN ACADEMY OF MEDICAL SCIENCES
Russia
Address
Kashirskoe Sh 34
115522 Moscow
Activity type
Research Organisations
Administrative Contact
Anastasia Grigorenko (Dr.)
INSTITUTE OF BIOCHEMISTRY AND GENETICS, UFA SCIENTIFIC CENTRE OF RAS
Russia
Address
Prospekt Oktyabrya 71
450054 Ufa
Activity type
Research Organisations
Administrative Contact
Elza Khusnutdinova (Prof.)
NII MEDICINSKOY GENETIKI TOMSKOGO NAUCHNOGO CENTRA SIBIRSKOGO OTDELENIYA ROSSIYSKOY AKADEMII MEDICINSKIH NAUK
Russia
Address
Naberezhnaya Ushayki 10
634050 Tomsk
Activity type
Research Organisations
Administrative Contact
Valery Puzyrev (Prof.)
University Medicine OOO
Russia
Address
Lomonosovsky Prospect 31, Bld. 5
119192 Moscow
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Larisa Samokhodskaya (Dr.)