Objective The subject of the proposal is the search and analysis of genomic variations underlying Alzheimer's disease (AD), alcoholism and schizophrenia – wide-spread diseases in human populations. Schizophrenia and alcoholism are common forms of behavior pathology and disability in adult life. AD is a most common form of dementia in human populations. Though the genomic variations presumably associated with AD, alcoholism and schizophrenia were described in preliminary studies for European populations, the significance of the putatively associated alleles, genetic background as well as the role of environmental factors is still poorly understood for them. Within the framework of this project we plan to extend the studies of genomic variations underlying these diseases by performing genome-wide association analysis in cohorts of patients and normal individuals from several ethnic populations of Europe and Russia.The genetic factors for cognition endophenotype will also be studied. Candidate regions, both newly found and reported previously for these diseases will be additionally analyzed by sequencing. Such large scale population studies combined with deep analysis of particular genes and genomic regions will allow us to reveal genetic reasons for susceptibility to these diseases. On the basis of this research we propose to contribute to development of a diagnostic instrument for the analysis of genetic risk factors for AD, alcoholism and schizophrenia. Comparison of several ethnic cohorts (different populations from Russia and Central/Western and Southern Europe) will also help to elucidate the influence of genetic background and environmental factors on the etiology of neuropsychiatric diseases. Consortium includes 6 groups from EU/AC and 7 groups from Russia. The participants are leading specialists in their fields and have joint publications on subjects related to this proposal. Fields of science natural sciencesbiological sciencesgeneticsmedical and health sciencesbasic medicineneurologydementiaalzheimermedical and health sciencesbasic medicinepathologymedical and health sciencesclinical medicinepsychiatryschizophrenia Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2009-4.3.3-1 - Comparative population genetic studies on multifactorial diseases (SICA) Call for proposal FP7-HEALTH-2009-single-stage See other projects for this call Funding Scheme CP-FP-SICA - Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries(SICA) Coordinator MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV EU contribution € 618 000,00 Address HOFGARTENSTRASSE 8 80539 Munchen Germany See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Joachim Gerlach (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (11) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITAT BASEL Switzerland EU contribution € 783 000,00 Address PETERSPLATZ 1 4051 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Andreas Papassotiropoulos (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands EU contribution € 378 000,00 Address DR MOLEWATERPLEIN 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Administrative Contact Koos (J.Th.N.) Lubbe (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KING'S COLLEGE LONDON United Kingdom EU contribution € 435 000,00 Address STRAND WC2R 2LS London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Silke Blohm (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT Germany EU contribution € 393 000,00 Address Square J 5 68159 Mannheim See on map Region Baden-Württemberg Karlsruhe Mannheim, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Simone Fuchs (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITATSKLINIKUM BONN Germany EU contribution € 393 000,00 Address VENUSBERG-CAMPUS 1 53127 Bonn See on map Region Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Beate Becker (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY OF RUSSIAN ACADEMY Russia EU contribution No data Address VAVILOV 32 119991 MOSCOW See on map Activity type Research Organisations Administrative Contact Alexander Zasedatelev (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Vavilov Institute of General Genetics - Russian Academy of Sciences Russia EU contribution No data Address Gubkin str. 3 119991 Moscow See on map Activity type Research Organisations Administrative Contact Irina Goldenkova-Pavlova (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NATIONAL RESEARCH CENTER OF MENTAL HEALTH - RUSSIAN ACADEMY OF MEDICAL SCIENCES Russia EU contribution No data Address Kashirskoe sh 34 115522 MOSCOW See on map Activity type Research Organisations Administrative Contact Anastasia Grigorenko (Dr.) Links Contact the organisation Opens in new window Total cost No data INSTITUTE OF BIOCHEMISTRY AND GENETICS, UFA SCIENTIFIC CENTRE OF RAS Russia EU contribution No data Address Prospekt Oktyabrya 71 450054 UFA See on map Activity type Research Organisations Administrative Contact Elza Khusnutdinova (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NII MEDICINSKOY GENETIKI TOMSKOGO NAUCHNOGO CENTRA SIBIRSKOGO OTDELENIYA ROSSIYSKOY AKADEMII MEDICINSKIH NAUK Russia EU contribution No data Address NABEREZHNAYA USHAYKI 10 634050 TOMSK See on map Activity type Research Organisations Administrative Contact Valery Puzyrev (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data University Medicine OOO Russia EU contribution No data Address Lomonosovsky prospect 31, bld. 5 119192 Moscow See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Larisa Samokhodskaya (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data