Objective
Cortical network function is strongly modulated by the action of GABA interneurons. Understanding the role of different types of interneurons in the generation of network patterns is thus essential. Developmental neurobiology offers both conceptual and experimental tools to address this question. Our research is centred on the integration of GABAergic microcircuits into a functional network during brain development. To describe cortical networks at the scale of microcircuits, we have developed a multidisciplinary approach that combines fast imaging of network dynamics, online data analysis, targeted electrophysiological recordings and histology (Cossart et al. 2005). Doing so, we found a major general step in the maturation of cortical networks. The first electrical network pattern, SPA (Synchronous Plateau Assemblies) emerges at birth and synchronizes electrically coupled neuronal assemblies (Crépel et al., 2007, Allene et al. 2008). We propose that SPAs are a critical step in the maturation of GABAergic microcircuits. More recently, we showed that developing hippocampal networks follow a scale-free topology and demonstrated the existence of functional hubs driving early network oscillations (Bonifazi et al. 2008). These cells are GABAergic neurons characterized by widespread axonal projections. These two findings provide the experimental foundation and conceptual framework for this project. We will address three objectives. First, we will perform a functional characterization of hub neurons orchestrating synchrony in developing cortical networks in vitro and in vivo. Second, we will address the role of SPA in the maturation GABAergic microcircuits. Last, we will examine circuit disorders related to developmental GABA Interneuropathies .
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences computer and information sciences data science
- natural sciences mathematics pure mathematics topology
- natural sciences biological sciences histology
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2009-StG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
13284 Marseille
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.