Objective
The aim of the project is to understand key steps in the molecular mechanisms of protein synthesis across species. The structure and function of pro- and eukaryotic (including human) ribosomes, those cellular nano-machineries that catalyse the decoding of genes, will be studied through an integrative, interdisciplinary structural biology approach. Since in the cell the ribosome is regulated by transiently binding protein and RNA factors, we plan the reconstitution and structural investigation of ribosome complexes in functionally defined states with regulatory proteins and messenger RNAs (mRNA). Four work packages will form the basis of the investigation, (i) the role of mRNA structure in gene expression in pro- and eukaryotes, (ii) the mechanism of translation initiation in prokaryotes as important antibiotic targets, (iii) the high-resolution structure of the human ribosome, and (iv) the architecture of eukaryotic polysomes, the functional protein synthesis entities of living cells. The complexes will be studied using a comprehensive approach which will incorporate biochemistry, structural biology, biophysics and bio-informatics, with cryo-electron microscopy and X-ray crystallography forming the core. The dynamic aspects of the protein synthesis machinery such as structural and functional transitions will be investigated by separation of multiple states through advanced image processing procedures, molecular dynamics simulations and by exploring new developments in optical imaging. Collaborations with leading laboratories have been set up in order to create an efficient framework for which the host institute provides an outstanding infrastructure. The project will provide fundamental knowledge on the mechanism of gene expression regulation at the level of protein synthesis contributing in the long term to the development of new drugs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences earth and related environmental sciences geology mineralogy crystallography
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biophysics
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences molecular biology structural biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2009-StG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
67404 Illkirch Graffenstaden
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.