Objective
The vertebrate limb is a model of paradigmatic value to decipher the mechanisms controlling cell-cell signalling during organogenesis. It has been shown that Sonic Hedgehog (SHH orchestrates not only limb development, but is a key regulator of vertebrate organogenesis. In spite of the established central role of SHH, recent studies by R. Zeller and apos;s group show that the early limb bud is pre-patterned much before the onset of SHH signalling. Accordingly, posterior restricted activation of Gremlin occurs prior to establishment of SHH signalling and the host group established that a novel type of distant cis-regulatory region with the characteristics of a Global Control Region (GCR) modulates transcriptional activation of Gremlin in the limb bud mesenchyme. The major goal of my research is to identify and study the trans-acting signals and cis-acting elements in the GCR mediating activation of gene expression prior to SHH signalling.
This study will provide insights of general relevance as it aims to unravel the earliest molecular events that initiate polarization of nascent cells. To this aim, I will culture and manipulate mouse limb buds from different null mutant embryos. Furthermore, I will use the most advanced mouse reverse genetics technology to generate the transgenic mice for my studies. Finally, my analysis will be of potential biomedical relevance as evidence is mounting that disruption of long-range cis-regulation underlies a larger that expected number of congenital malformations and diseases. Indeed, this project contrasts with my previous research dealing primarily with phenotypic analysis of mouse embryos with impaired retinoic acid signalling. Therefore, this post-doctoral training period will allow me to substantially extend my technical and scientific knowledge.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- medical and health sciences clinical medicine embryology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BASEL
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.