Objective
We propose to study the properties of polymers in conditions where confined geometries dramatically reduce the accessible volume. The properties of polymers can change significantly under such conditions, and there are important applications both in materi al science and in biological systems. In the biological world confinement occurs during important processes like the translocation of biopolymers through pores in cell or nucleus membranes, or during the encapsulation in small compartments (misfolded prote ins in chaperonin complexes).We propose to study the fundamental properties of the flow of polymers through such biological pores, which, although complex in the number of parameters involved, are not conceptually complicated. A computer simulation of such a system will then be a powerful tool to understand what the relevant parameters are that determine the system's behavior. The computational methods we will develop are largely inspired by successful techniques from the field of colloid science. In partic ular we combine Stochastic Rotational Dynamics scheme with a coarse grained representation of the biopolymer. For this last point we will extend the recent experience gained on design of configurational changes in protein and of protein-protein interaction s to a continuous representation of the amino acid chain. The model will then provide at the same time a general description of the mechanical action of the confinement, and how it depends on the interactions between the protein and the nanopore/nanocage.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences chemical sciences polymer sciences
- natural sciences physical sciences classical mechanics statistical mechanics
- natural sciences chemical sciences organic chemistry amines
- natural sciences mathematics applied mathematics mathematical model
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.