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Molecular Approaches and MetaGenomic Investigations for optimizing Clean-up of PAH contaminated sites

Objective

MAGICPAH aims to explore, understand and exploit the catalytic activities of microbial communities involved in the degradation of persistent PAHs. It will integrate (meta-) genomic studies with in-situ activity assessment based on stable isotope probing particularly in complex matrices of different terrestrial and marine environments. PAH degradation under various conditions of bioavailability will be assessed as to improve rational exploitation of the catalytic properties of bacteria for the treatment and prevention of PAH pollution. We will generate a knowledge base not only on the microbial catabolome for biodegradation of PAHs in various impacted environmental settings based on genome gazing, retrieval and characterization of specific enzymes but also on systems related bioavailability of contaminant mixtures. MAGICPAH takes into account the tremendous undiscovered metagenomic resources by the direct retrieval from genome/metagenome libraries and consequent characterization of enzymes through activity screens. These screens will include a high-end functional small-molecule fluorescence screening platform and will allow us to directly access novel metabolic reactions followed by their rational exploitation for biocatalysis and the re-construction of biodegradation networks. Results from (meta-) genomic approaches will be correlated with microbial in situ activity assessments, specifically dedicated to identifying key players and key reactions involved in anaerobic PAH metabolism. Key processes for PAH metabolism particularly in marine and composting environments and the kinetics of aerobic degradation of PAH under different conditions of bioavailability will be assessed in model systems, the rational manipulation of which will allow us to deduce correlations between system performance and genomic blueprint. The results will be used to improve treatments of PAH-contaminated sites.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

FP7-KBBE-2009-3
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Address
Inhoffenstrasse 7
38124 Braunschweig
Germany
Activity type
Research Organisations
EU contribution
€ 435 890
Administrative Contact
Michael Strätz (Dr.)

Participants (13)

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 296 745
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Carlos Manuel Abad Ruiz (Mr.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 303 534
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Gaetana Irrera (Ms.)
BANGOR UNIVERSITY
United Kingdom
EU contribution
€ 301 296
Address
College Road
LL57 2DG Bangor
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christine Davey (Ms.)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 274 524
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Birte Kastrup Rasmussen (Ms.)
AECOM CZ SRO
Czechia
EU contribution
€ 171 155
Address
Trojska 92
171 00 Prague 7
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Vendulka Spiskova (Dr.)
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 284 505
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
Regis Copin (Mr.)
HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ
Germany
EU contribution
€ 305 475
Address
Permoserstrasse 15
04318 Leipzig
Activity type
Other
Administrative Contact
Annette Schmidt (Ms.)
AARHUS UNIVERSITET
Denmark
EU contribution
€ 320 160
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Britt Sønberg Vilstrup (Ms.)
SYNDIAL SPA - ATTIVITA DIVERSIFICATE
Italy
EU contribution
€ 50 005
Address
Piazza Boldrini 1
20097 San Donato Milanese
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Giovanni Trovato (Dr.)
CORPORACION CORPOGEN
Colombia
EU contribution
€ 139 086
Address
Carrera 5 N° 66A-34
N/A Bogota
Activity type
Research Organisations
Administrative Contact
Luis Fernando Diaz (Mr.)
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
Canada
Address
Kings College Circle 27
M5S 1A1 Toronto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alexei Savchenko (Dr.)
UNIVERSITAET LEIPZIG

Participation ended

Germany
EU contribution
€ 89 871,04
Address
Ritterstrasse 26
04109 Leipzig
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerhard Fuchs (Mr.)
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
EU contribution
€ 24 890,96
Address
Fahnenbergplatz
79098 Freiburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gabriela Hafke-Wessel (Mrs.)