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From Biodiversity to Chemodiversity: Novel Plant Produced Compounds with Agrochemical and Cosmetic interest

Objectif

The consortium will discover and carry to the stage of development candidates, plant derived small molecules with potential as new cosmetic and agrochemical agents. These compounds will derive from plants originating from major biodiversity hotspots in Europe, Africa, Latin America, and the Asia-Pacific region. The starting point of the project will be a diversity-oriented natural product library of 500 compounds from the existing compound repositories of three project partners. Screening of this compound library in assay panels for agrochemical (antifungal, herbicidal, insecticidal) and cosmetic properties (UV-protection, anti-aging, anti-hyperpigmentation) will rapidly identify promising scaffolds. This knowledge will serve as entry points for a chemotaxonomy and chemodiversity oriented collection of plants which are thought to contain structural variants and decorations of these scaffolds. A liquid library of 3600 extracts will be generated and screened. Stringent prioritization and profiling procedures will generate 100 compounds as focused sub-libraries around the privileged scaffolds. A state-of-the-art technology platform for miniaturized natural product discovery will be used for the purpose. Evaluation of these sub-libraries will lead to 30 compounds which will undergo advanced testing to qualify 5 compounds as development candidates for novel agrochemical and/or cosmetic agents with new or improved properties over existing active ingredients. An additional outcome of the project will be an extract library with a unprecedented level of associated spectroscopic information and metadata, to be used for future purposes. The high-caliber consortium brings together international leaders in small molecule natural products, bioprospection, leading industries in agrochemistry, cosmetics, and spectroscopic data management and analysis.

Appel à propositions

FP7-KBBE-2009-3
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Coordinateur

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Adresse
6 Christou Lada Str
10561 Athina
Grèce

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Efi Kafentzi (Ms.)
Contribution de l’UE
€ 706 753,40

Participants (8)

UNIVERSITAT BASEL
Suisse
Contribution de l’UE
€ 378 045
Adresse
Petersplatz 1
4051 Basel

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Matthias Hamburger (Prof.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Contribution de l’UE
€ 665 301,60
Adresse
Rue Michel Ange 3
75794 Paris

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Type d’activité
Research Organisations
Contact administratif
Véronique Debisschop (Mrs.)
UNIVERSIDAD DE PANAMA
Panama
Contribution de l’UE
€ 80 680
Adresse
Calle Manuel Espinosa Batista Sn
0824 Panama

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Betty Ann Rowe De Catsambanis (Prof.)
COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH
Afrique du Sud
Contribution de l’UE
€ 210 243
Adresse
Meiring Naude Road, Brummeria 46
0001 Pretoria

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Type d’activité
Research Organisations
Contact administratif
Sandy Farnworth (Ms.)
BASF SE
Allemagne
Contribution de l’UE
€ 308 690
Adresse
Carl Bosch Strasse 38
67063 Ludwigshafen Am Rhein

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Michael Roeper (Dr.)
KORRES S.A. NATURAL PRODUCTS (KORRES ANONIMI ETERIA FYSIKA PROIONTA)
Grèce
Contribution de l’UE
€ 281 120
Adresse
57th Km Athens-lamia National Road
32011 Inofyta

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Dimitris Vidakis (Mr.)
BRUKER BIOSPIN GMBH
Allemagne
Contribution de l’UE
€ 172 800
Adresse
Rudolf-plank-strasse 23
76275 Ettlingen

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Eberhard Eckert (Mr.)
"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""
Grèce
Contribution de l’UE
€ 100 000
Adresse
End Of Patriarchou Grigoriou E And 27 Neapoleos Street
15341 Agia Paraskevi

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Type d’activité
Research Organisations
Contact administratif
Marina Fontara