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Improved gene transfer system to iPS cells in mouse

Objective

The scientific aim of InduVir is to produce novel comparative information on the generation, maintenance and characteristics of iPS cells in mouse and on their differentiation towards different, especially cardiac lineages. In InduVir we are aiming to develop a novel system, by using removable transposons and polycistronic, deletable lentiviruses and therefore significantly reduce the risk of malignant transformations associated with conventional iPS technologies. Technical focus will be developing a novel and potentially patentable technology in Europe for reprogramming somatic cells to an embryonic state, which have a excellent potential for future cell based therapy. InduVir will also develop methods for targeted differentiation of the iPS cells to cardiac cells. We expect to get novel information on pathways and transcriptional networks that regulate differentiation and lineage specification. The differentiated cardiac tissues would provide superior tools for pharmacological studies or high-throughput screening. IPS technology has the great potential to generate patient and disease specific stem cells and derivates, yet it lacks many of the technical, ethical and legal issues associated with human ES cell research including therapeutic cloning.The information generated by these studies will contribute to stem cell therapy and modern regenerative medicine.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/medical biotechnology/genetic engineering/gene therapy

Call for proposal

FP7-PEOPLE-2009-RG
See other projects for this call

Funding Scheme

MC-IRG - International Re-integration Grants (IRG)

Coordinator

BIOTALENTUM TUDASFEJLESZTO KFT
Address
Aulich Lajos Utca 26
2100 Goedoello
Hungary
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 100 000
Administrative Contact
Andras Dinnyes (Prof.)