Objective Medical diagnosis is currently undergoing a major revolution due to the fast discovery of molecular biomarkers, and the development of multimodal “metabiomarker” signatures. Progress, however, is hindered by low abundance of many biomarkers of interest in body fluids, in absolute concentration and with regard to other biomolecules. The aim of the present project is to apply these progresses in biotechnology, nanoparticle synthesis, and nano-instrumentation to the development of fully integrated lab-on chip instruments able to perform elaborate multimodal biomarker analysis on a routine basis and at the ultrasensitive level required to allow minimally invasive tests. In particular, we aim at overcoming a major bottleneck on the path to this objective, which was identified in a previous project in the “HEALTH” priority: no satisfactory solution currently exists to bridge the several orders of magnitude between the nanoscale volumes at which ultrasensitive new generation sensors operate, and the often millilitre volumes of samples in which the molecules of interest must be found. For this, we shall combine innovations in pre-concentration, micro and nanofluidics, self-assembly, micro-nanofabrication, and nanodetection. The project will develop a generic, multipurpose, platform of compatible enabling technologies, and integrate them into devices. In order to maximize impact and societal benefit, the project will be validated on an application of major interest for health, namely the early detection of biomarkers for neurodegenerative diseases (including Alzheimer), with special emphasis on subtyping of these diseases for improved treatment strategies. The consortium includes a multidisciplinary group of technology developers, three leading biomedical groups in clinical neuroscience for definition of specifications and end-user pre-clinical validation, and three research-oriented SMEs in biotechnology, nanosensing and microfluidics. Fields of science natural sciencesbiological sciencesneurobiologynatural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicsmedical and health sciencesbasic medicineneurologydementiaalzheimernatural sciencesbiological sciencesbiochemistrybiomoleculessocial sciencespolitical sciencespolitical transitionsrevolutions Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP-2009-4.0-3 - Development of nanotechnology-based systems for molecular diagnostics and imaging Call for proposal FP7-NMP-2009-LARGE-3 See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator DANMARKS TEKNISKE UNIVERSITET Address Anker engelunds vej 101 2800 Kongens lyngby Denmark See on map Region Danmark Hovedstaden Københavns omegn Activity type Higher or Secondary Education Establishments Administrative Contact Kirsten Gelting (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (17) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITE PARIS-SUD France EU contribution € 670 613,50 Address Rue georges clemenceau 15 91405 Orsay cedex See on map Activity type Higher or Secondary Education Establishments Administrative Contact Sandra Mereu (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERZITA PARDUBICE Czechia EU contribution € 453 067,20 Address Studentska 95 532 10 Pardubice See on map Region Česko Severovýchod Pardubický kraj Activity type Higher or Secondary Education Establishments Administrative Contact Zuzana Bilkova (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data USTAV MAKROMOLEKULARNI CHEMIE AV CRVVI Czechia EU contribution € 437 124,00 Address Heyrovsky sq 2 162 06 Praha 6 See on map Region Česko Praha Hlavní město Praha Activity type Research Organisations Administrative Contact Jan Kouba (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data INSTITUT CURIE France EU contribution € 1 243 927,60 Address Rue d ulm 26 75231 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Corinne Cumin (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITAET ULM Germany EU contribution € 579 000,00 Address Helmholtzstrasse 16 89081 Ulm See on map Region Baden-Württemberg Tübingen Ulm, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Frank Gleixner (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITAETSKLINIKUM ESSEN Germany EU contribution € 336 562,00 Address Hufelandstrasse 55 45147 Essen See on map Region Nordrhein-Westfalen Düsseldorf Essen, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Sebastian George (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data DIAGNOSWISS SA Switzerland EU contribution € 564 182,60 Address Zi les ilettes secteur 4 1870 Monthey See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Emmanuel Dubosson (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data FLUIGENT SA France EU contribution € 711 566,97 Address 57-77 avenue de fontainebleau 94270 Le kremlin-bicetre See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jacques Goulpeau (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data MORAVIAN-BIOTECHNOLOGY, SPOL.SRO Czechia EU contribution € 213 879,70 Address Bohuslava martinu 90 60200 Brno stred See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Rudolf Nenutil (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data KUNGLIGA TEKNISKA HOEGSKOLAN Sweden EU contribution € 714 072,00 Address Brinellvagen 8 100 44 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Susanna De Meyere (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ITA-SUOMEN YLIOPISTO Finland EU contribution € 180 559,60 Address Yliopistonranta 8 70211 Kuopio See on map Region Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Savo Activity type Higher or Secondary Education Establishments Administrative Contact Hilkka Soininen (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data CONSIGLIO NAZIONALE DELLE RICERCHE Italy EU contribution € 331 191,25 Address Piazzale aldo moro 7 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Administrative Contact Segio Riva (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA Spain EU contribution € 664 892,25 Address Campus de la uab edifici q icn2 08193 Cerdanyola del valles See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact Stewe Bekk (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS France EU contribution € 144 889,38 Address Boulevard saint michel 60 75272 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Florence Thepenier (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data RAMBOLL DANMARK AS Denmark EU contribution € 212 250,00 Address Hannemanns allee 53 2300 Kobenhavn See on map Region Danmark Hovedstaden Byen København Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jesper Pedersen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data KOBENHAVNS UNIVERSITET Denmark EU contribution € 51 360,00 Address Norregade 10 1165 Kobenhavn See on map Region Danmark Hovedstaden Byen København Activity type Higher or Secondary Education Establishments Administrative Contact Bjarne Friis Ploumark (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS Germany EU contribution € 223 200,00 Address Robert-koch-strasse 40 37075 Goettingen See on map Region Niedersachsen Braunschweig Göttingen Activity type Higher or Secondary Education Establishments Administrative Contact Christiane Hennecke (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
