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Nanosystems for the early Diagnosis of Neurodegenerative diseases

Objective

Medical diagnosis is currently undergoing a major revolution due to the fast discovery of molecular biomarkers, and the development of multimodal “metabiomarker” signatures. Progress, however, is hindered by low abundance of many biomarkers of interest in body fluids, in absolute concentration and with regard to other biomolecules. The aim of the present project is to apply these progresses in biotechnology, nanoparticle synthesis, and nano-instrumentation to the development of fully integrated lab-on chip instruments able to perform elaborate multimodal biomarker analysis on a routine basis and at the ultrasensitive level required to allow minimally invasive tests. In particular, we aim at overcoming a major bottleneck on the path to this objective, which was identified in a previous project in the “HEALTH” priority: no satisfactory solution currently exists to bridge the several orders of magnitude between the nanoscale volumes at which ultrasensitive new generation sensors operate, and the often millilitre volumes of samples in which the molecules of interest must be found. For this, we shall combine innovations in pre-concentration, micro and nanofluidics, self-assembly, micro-nanofabrication, and nanodetection. The project will develop a generic, multipurpose, platform of compatible enabling technologies, and integrate them into devices. In order to maximize impact and societal benefit, the project will be validated on an application of major interest for health, namely the early detection of biomarkers for neurodegenerative diseases (including Alzheimer), with special emphasis on subtyping of these diseases for improved treatment strategies. The consortium includes a multidisciplinary group of technology developers, three leading biomedical groups in clinical neuroscience for definition of specifications and end-user pre-clinical validation, and three research-oriented SMEs in biotechnology, nanosensing and microfluidics.

Call for proposal

FP7-NMP-2009-LARGE-3
See other projects for this call

Coordinator

DANMARKS TEKNISKE UNIVERSITET
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Denmark
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 267 661,95
Administrative Contact
Kirsten Gelting (Ms.)

Participants (17)

UNIVERSITE PARIS-SUD
France
EU contribution
€ 670 613,50
Address
Rue Georges Clemenceau 15
91405 Orsay Cedex
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sandra Mereu (Ms.)
UNIVERZITA PARDUBICE
Czechia
EU contribution
€ 453 067,20
Address
Studentska 95
532 10 Pardubice
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Zuzana Bilkova (Ms.)
USTAV MAKROMOLEKULARNI CHEMIE AV CRVVI
Czechia
EU contribution
€ 437 124
Address
Heyrovsky Sq 2
162 06 Praha 6
Activity type
Research Organisations
Administrative Contact
Jan Kouba (Mr.)
INSTITUT CURIE
France
EU contribution
€ 1 243 927,60
Address
Rue D'ulm 26
75231 Paris
Activity type
Research Organisations
Administrative Contact
Corinne Cumin (Ms.)
UNIVERSITAET ULM
Germany
EU contribution
€ 579 000
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Gleixner (Mr.)
UNIVERSITAETSKLINIKUM ESSEN
Germany
EU contribution
€ 336 562
Address
Hufelandstrasse 55
45147 Essen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sebastian George (Mr.)
DIAGNOSWISS SA
Switzerland
EU contribution
€ 564 182,60
Address
Zi Les Ilettes Secteur 4
1870 Monthey
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Emmanuel Dubosson (Mr.)
FLUIGENT SA
France
EU contribution
€ 711 566,97
Address
57-77 Avenue De Fontainebleau
94270 Le Kremlin-bicetre
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jacques Goulpeau (Dr.)
MORAVIAN-BIOTECHNOLOGY, SPOL.SRO
Czechia
EU contribution
€ 213 879,70
Address
Bohuslava Martinu 90
60200 Brno Stred
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rudolf Nenutil (Dr.)
KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
EU contribution
€ 714 072
Address
Brinellvagen 8
100 44 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Susanna De Meyere (Ms.)
ITA-SUOMEN YLIOPISTO
Finland
EU contribution
€ 180 559,60
Address
Yliopistonranta 1 E
70211 Kuopio
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hilkka Soininen (Prof.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 331 191,25
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Segio Riva (Dr.)
FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA
Spain
EU contribution
€ 664 892,25
Address
Campus De La Uab Edifici Q Icn2
08193 Bellaterra (Barcelona)
Activity type
Research Organisations
Administrative Contact
Stewe Bekk (Mr.)
ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS
France
EU contribution
€ 144 889,38
Address
Boulevard Saint Michel 60
75272 Paris
Activity type
Research Organisations
Administrative Contact
Florence Thepenier (Ms.)
RAMBOLL DANMARK AS
Denmark
EU contribution
€ 212 250
Address
Hannemanns Allee 53
2300 Kobenhavn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jesper Pedersen (Mr.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 51 360
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bjarne Friis Ploumark (Mr.)
UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Germany
EU contribution
€ 223 200
Address
Robert-koch-strasse 40
37075 Goettingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christiane Hennecke (Mrs.)