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Improved prediction of HIV drug resistance in different viral subtypes by bioinformatic analysis of genetic and clinical data

Objective

Since the advent of the HIV epidemic, more than 25 million people have died from AIDS. Antiretroviral therapy (ART) has dramatically decreased to mortality and morbidity in high income countries. However, the virus adapts rapidly during suboptimal therapy and over 200 mutations are associated with resistance to one or more drugs. Drug resistance is thus a major threat to the long-term outcome of ART. The EuResist project is the worlds largest database and has created a prediction engine, based on a combination of HIV genetic data, treatment history and clinical response, from over 33,000 patients from six European countries. The amount of data and participating countries, are ontinuously increasing. Given the viral DNA sequence and patient clinical data, EuResist can recommend the therapy most likely to effectively suppress the viral load, and avoid drug combinations likely to fail due to resistance. Currently, the data is mainly retrieved from HIV subtype B, since this viral type is the most common in Europe. One of the main aims of the project is therefore to enhance the prediction for other subtypes, e.g. subtype C, which is the most common in Africa and world-wide. This will be achieved through addition of new data from patients infected with different viral subtypes, both from Sweden and from collaborating institutes in Ethiopia, Tanzania and South Africa. Furthermore, we will perform thorough bioinformatic analysis of mutational patterns in relation to the viral subtype, where the ultimate goal is to create a valid treatment prediction based on clinical data and treatment history, without the need for viral DNA sequence data. If this is achieved it will be a highly important contribution to the fight against AIDS in low and middle-income countries.

Field of science

  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance
  • /natural sciences/biological sciences/genetics and heredity/mutation
  • /social sciences/sociology/demography/mortality
  • /humanities/history and archaeology/history

Call for proposal

FP7-PEOPLE-2009-RG
See other projects for this call

Funding Scheme

MC-ERG - European Re-integration Grants (ERG)

Coordinator

KAROLINSKA INSTITUTET
Address
Nobels Vag 5
17177 Stockholm
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 45 000
Administrative Contact
Klas Karlsson (Mr.)