Final Report Summary - IMMEEDIA (Immunomodulatory Effects of Exercise in Type 1 Diabetes)
The general objective of this grant was to understand the extent to which exercise may ameliorate the progression of the autoimmune process and inflammatory pathways associated with beta cell dysfunction/destruction in type 1 diabetes (T1DM) and type 2 diabetes (T2DM).
To verify whether exercise was capable of counteracting the T1DM-autoimmune process directed against beta-cells of the pancreatic islets, our consortium envisaged a multi-approach strategy consisting of:
- administration of a tailored exercise training program in different cohorts of T1DM-subjects;
- in-vivo animal models challenged with exercise;
- cell studies to analyse the exercise effects on signal transduction pathways and cytokine responses;
A common thread across the spectrum of diabetes is the dysregulation of immune system function, and beta-cell toxicity is mediated by a complex interplay between oxidative stress and inflammation, for which exercise could be protective. It is nowadays clear that marked immune aberrancies are linked to several metabolic disease. Exercise is a cornerstone in the prevention, cure and treatment of all-species metabolic disturbances.
This exchange scheme aimed at developing research and training activities, specifically those in which physical exercise could be beneficial for the treatment of TD1M.
To verify whether exercise was capable of counteracting the T1DM-autoimmune process directed against beta-cells of the pancreatic islets, our consortium envisaged a multi-approach strategy consisting of:
- administration of a tailored exercise training program in different cohorts of T1DM-subjects;
- in-vivo animal models challenged with exercise;
- cell studies to analyse the exercise effects on signal transduction pathways and cytokine responses;
A common thread across the spectrum of diabetes is the dysregulation of immune system function, and beta-cell toxicity is mediated by a complex interplay between oxidative stress and inflammation, for which exercise could be protective. It is nowadays clear that marked immune aberrancies are linked to several metabolic disease. Exercise is a cornerstone in the prevention, cure and treatment of all-species metabolic disturbances.
This exchange scheme aimed at developing research and training activities, specifically those in which physical exercise could be beneficial for the treatment of TD1M.