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Immunomodulatory Effects of Exercise in Type 1 Diabetes

Final Report Summary - IMMEEDIA (Immunomodulatory Effects of Exercise in Type 1 Diabetes)

The general objective of this grant was to understand the extent to which exercise may ameliorate the progression of the autoimmune process and inflammatory pathways associated with beta cell dysfunction/destruction in type 1 diabetes (T1DM) and type 2 diabetes (T2DM).
To verify whether exercise was capable of counteracting the T1DM-autoimmune process directed against beta-cells of the pancreatic islets, our consortium envisaged a multi-approach strategy consisting of:
- administration of a tailored exercise training program in different cohorts of T1DM-subjects;
- in-vivo animal models challenged with exercise;
- cell studies to analyse the exercise effects on signal transduction pathways and cytokine responses;
A common thread across the spectrum of diabetes is the dysregulation of immune system function, and beta-cell toxicity is mediated by a complex interplay between oxidative stress and inflammation, for which exercise could be protective. It is nowadays clear that marked immune aberrancies are linked to several metabolic disease. Exercise is a cornerstone in the prevention, cure and treatment of all-species metabolic disturbances.
This exchange scheme aimed at developing research and training activities, specifically those in which physical exercise could be beneficial for the treatment of TD1M.