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Functional and structural analysis of bacterial membrane transporters

Objective

Membrane transport proteins play crucial roles in fundamental cellular processes and functions in all organisms. A substantial proportion of prokaryotic genes are predicted to encode membrane transporters, emphasising the importance of transporters in their lifestyles. In silico analysis of sequenced Acinetobacter baumannii and Bacillus cereus group strains has revealed the presence of an unprecedented high number (over 100) of multidrug resistance (MDR) efflux pumps in these pathogenic bacteria.
The current project is a collaboration between three partners, two European and an Australian research group. The project aims to increase our knowledge about the membrane transport processes with regards to their role in microbial pathogenesis and resistance to antimicrobials. The project also aims to illuminate the evolutionary relatedness and structure-function relationships of membrane transport proteins.

Call for proposal

FP7-PEOPLE-2009-IRSES
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Funding Scheme

MC-IRSES - International research staff exchange scheme (IRSES)

Coordinator

UNIVERSITETET I OSLO
Address
Problemveien 5-7
0313 Oslo
Norway
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 39 600
Administrative Contact
Rigmor Bjorkli (Prof.)

Participants (1)

UNIVERSITY OF LEEDS
United Kingdom
EU contribution
€ 19 800
Address
Woodhouse Lane
LS2 9JT Leeds
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kathy Brownridge (Ms.)