Light microscopy has many applications in the life and health sciences. These applications include drug screening, in vitro fertilization, medical diagnostics and basic research in cell and systems biology [ref]. Many of these applications require the imaging of multiple samples over extended periods of times using a methodology that is often referred to as High Content Screening (HCS). Systems for performing HCS do exist, however thes systems generally provide a solution for a limited range of problems. Consequently there are many systems for which no suitable HCS technology is available. The first system involves a culture of primary naïve T-cells in conjunction with antigen presenting dendritic cells (APCs), which is used for studying the biology of T-cell activation. The second system involves nvolves the culture of primary rat neurons transfected to express fluorescently labelled synapse markers on Multi-Electrode Arrays (MEAs) dishes. This system is being used to study the connection between neural network structure and the electric activity of the network. We propose to develop novel software and hardware technology that will enable efficient research using these systems.
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