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Development of systems for high content screening of live cells

Objective

Light microscopy has many applications in the life and health sciences. These applications include drug screening, in vitro fertilization, medical diagnostics and basic research in cell and systems biology [ref]. Many of these applications require the imaging of multiple samples over extended periods of times using a methodology that is often referred to as High Content Screening (HCS). Systems for performing HCS do exist, however thes systems generally provide a solution for a limited range of problems. Consequently there are many systems for which no suitable HCS technology is available. The first system involves a culture of primary naïve T-cells in conjunction with antigen presenting dendritic cells (APCs), which is used for studying the biology of T-cell activation. The second system involves nvolves the culture of primary rat neurons transfected to express fluorescently labelled synapse markers on Multi-Electrode Arrays (MEAs) dishes. This system is being used to study the connection between neural network structure and the electric activity of the network. We propose to develop novel software and hardware technology that will enable efficient research using these systems.

Field of science

  • /natural sciences/computer and information sciences/software
  • /medical and health sciences/health sciences

Call for proposal

FP7-PEOPLE-2009-RG
See other projects for this call

Funding Scheme

MC-IRG - International Re-integration Grants (IRG)

Coordinator

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Address
Senate Building Technion City
32000 Haifa
Israel
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 50 000
Administrative Contact
Mark Davison (Mr.)