Objective
Natural products represent a pool of privileged structures that are optimized by evolution to interact with proteins and other biomolecules. The enormous structural diversity of natural products thus provides an indispensable resource in an effective search for new therapeutic agents. Plants are of particular interest as source of pharmaceutically active compounds since they are used to treat diseases and maintain health since prehistoric times. They produce an enormous variety of substances that play a role in the plant defense mechanisms against predation by microorganisms, insects, and herbivores. The classical phytochemical approach in drug discovery focuses on secondary metabolites such as glycosides, phenolics, carbohydrates, alkaloids and terpenoids. The therapeutic potential of plant peptides and proteins, on the other hand, is by far less well studied and has only recently gained broader interest. The main reason for this is that standard proteomic and metabolomic approaches are not suitable for a systematic peptide analysis. For that reason, we are aiming at developing a peptidomic workflow using ultra-high performance chromatography and state-of-the-art mass spectrometry to cover the mass range of interest for the detection of plant peptides. The focus of the proposed project is the identification, isolation and characterisation of novel pharmacologically active peptides and mini-proteins from different plant species. Of particular interest are small (less than 100 amino acid residues), cysteine-rich peptides and proteins (CRPs), and in particular cyclotides, that often show remarkable antimicrobial, antifungal, antiviral and insecticidal activity as well as other pharmacologically interesting effects.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- natural sciences biological sciences biological behavioural sciences ethology biological interactions
- natural sciences chemical sciences organic chemistry amines
- natural sciences chemical sciences analytical chemistry mass spectrometry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-RG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1010 WIEN
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.