Objective
The use of formalin-fixed specimens in genetic studies has been limited due to damage of the nucleic acids through contact with the formalin. However, recent developments in extraction and repair techniques have increased both the yields and quality of the DNA and RNA sequences that can be retrieved from such specimens. Additionally, the invention of advanced Multi-Plex PCR techniques has made it possible to quickly screen a large number of genomic markers. Thus, for the first time, formalin-fixed specimens have become available to large-scale genetic analyses.This proposal will enable the principal applicant to become an expert on the retrieval and analyses of nucleic acid from formalin fixed specimens. Based at the University of Copenhagens Centre for Anci ent DNA and Evolutionary Biology, the applicant will be trained by a team of expert mentors in the use, design and theory behind modern high-throughput genetic screening assays for ancient and contemporary DNA. He will also be trained in advanced statistic al and analytical techniques required to develop and analyze the data from genetic association studies. The applicant will apply these techniques to anonymous, HIV-1 infected, fixed biopsy and autopsy specimens that date to the early period of the epidemic in Northern Europe (and lt 1990). Thereby, he will investigate the dynamics of the evolutionary interaction between HIV-1 and the human genome, principally focusing on association studies between the virus and the Human Leukocyte Antigen (HLA) system. The outcomes of this project will not only confirm current hypotheses, and shed new insights, into the model HIV-1-human system, but will develop the tools through which future investigations that require high-throughput screening techniques of fixed specimen s can be achieved.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules nucleic acids
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences evolutionary biology
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
COPENHAGEN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.