Objective
The deciphering of the human genome laid the ground for a far more challenging task: the understanding of the intricate and diverse mode of action of the gene products, the proteins. The relative lack of appropriate technologies capable to deal with this c omplexity, makes the functional, molecular deconvolution of the proteome a still distant scientific goal of prime importance. Our research will develop and use novel enzyme microarray technologies (EMTs), a uniquely powerful tool for activity-based proteom ics. This technology relies, among other novelties, on the development of a variety of chemical probes that will monitor the activity of a multitude of microarrayed enzymes. We will use the enzyme microarray technology in our laboratory in conjunction with designed chemical libraries in order to perform a detailed, en masse, molecular understanding of the activity of important families of enzymes such as proteases, enzymes involved in phosphorylation/dephosphorylation, as well as of enzymes involved in the ubiquitination pathway. Large scale specificity correlations between the substrate specificity profiles of enzymes from these families will substantiate new hypothesis about the involvment of important enzymes in networks that govern many important biochem ical processes. The versatility and reliability of this technology can be used in two practically relevant formats: High-Throughput Screening and activity-based diagnostics. Our research is directly relevant to the Thematic Priority 1 of FP6 and will be ac hieved through the creation of a team involving the international mobility of the team members.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences chemical sciences polymer sciences
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-8
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.