Objective
The thymus is a central lymphoid organ, which is of particular interest since it is the unique site responsible for T lymphocyte development. Failure to form a thymus results in profound immunodeficiency such as in the nude mouse or in humans affected by D i-George syndrome.
Moreover, aberrant thymus structures such as in thymoma are possibly involved in autoimmunity. The study of PKB has been moving from a cellular to a whole organism context, highlighting tissue-specific functions of the different PKB isoforms in adult metabolism and normal development. Preliminary studies in our laboratory on PKB mutant mice have shown that haplo-insufficiency of PKBgamma in a PKBalpha null-background reduces the survival of mice and leads to major thymic defects, as observed in three-day-old mice.
In view of our preliminary in vivo observation, we will take advantage of PKB mouse models available in house to understand and determine the role of not only PKBalpha and PKBgamma, but also PKBbeta, at different stages of thymus development and physiology.
To do so, we will
- study the expression profile and pattern of PKB isoforms in mouse thymus at different stages of development and life,
- extensively analyze the thymus in different PKB mouse models and extend in parallel the study to a secondary lymphoid tissue, the spleen, and finally
- uncover the mechanism involved.
Results obtained from this study are expected to provide insights into the role of PKB in thymus development and physiology, and hopefully identify new molecular markers and novel potential pharmacological targets in diseases such as immunodeficiency and autoimmunity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine physiology
- natural sciences biological sciences zoology mammalogy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BASEL
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.