Objective
The molecular and cellular basis of variation in leaf size and shape is poorly understood. Oriented cell divisions initiate (pro) vascular strands, and inversely the vascular tissue supplies growth factors to the leaf facilitating growth and division. Ther efore cell division and vascularization are functionally linked. Temporal characterization of cell division and expansion in wild-type and mutant Arabidopsis leaves, and parallel transcript profiling generated a unique set of growth related gene-expression data. Modeling is essential to establish functional relationships in these data. To connect ongoing top-down and bottom-up models we propose a dynamic, multicellular model of the developing Arabidopsis leaf. We start by modeling the oriented divisions ini tiating the procambium, driven by the interaction between oriented auxin transport and the presence of a second morphogen, e.g. a flavonoid. This suggests a feedback mechanism explaining vascular patterning. Secondly, we model the cross-talk between divisi on/growth and vasculogenesis. Eventually the model must become a hypothesis generator, and predict the effect of perturbations, which we can test against analyses of existing mutant plants. Thus the model becomes a crucial tool to link molecular processes involved in growth factor signaling, cell cycle and growth regulation and the morphogenesis of the leaf as a whole.The host coordinates the EU funded CAGE project which generates a data-set of 2000 micro-array gene-expression profiles. I will join a mult idisciplinary team of biologists, computer scientists and physicists, analyzing the plant growth regulatory system this data represents. My task will be to develop a model of leaf development which integrates cell cycle and cell division data. The project would allow me to further develop my career as a computational biologist, specializing in modeling multicellular development, at the same time gaining experience in the field of plant development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- natural sciences biological sciences botany
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
GENT
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.