Objective
Animals develop all their organs entirely during embryogenesis. On the contrary, only few organs are established during plant embryogenesis. The development of all the plant organs depends on post-embryonic activity of the shoot apical meristem (SAM) and t he root meristem, which are established during embryogenesis.
Plant development and growth depends on the ability of the SAM to renew itself and at the same time differentiate into various organs. These processes are strictly regulated and coordinated by meristematic genes, by local hormonal balance and by abiotic stimuli.
In plants, the class 1 KNOX (KNOTTED1-like) family plays an important role in the formation and maintenance of the SAM. KNOX gene expression is first detected as the meristem is established in the embryo and disappears from cells that will give rise to leaf primordia. Over-expression of KNOX genes strongly affects cell fate.
Altered cell differentiation produces dramatic changes of the whole plant architecture and leaf morphology. Mutations of some class 1 genes result in seedlings that germinate, but fail to develop any further. KNOX proteins interact with other homeodomain proteins (BELL). In animals the KNOX/BELL complex contains at least 3 subunits. In plants, KNOX and BELL proteins interact and bind the same nucleotide sequence.
These findings support the hypothesis that a third interactor must provide binding-site specificity for the differential regulation of KNOX target genes. We propose a multidisciplinary project aimed at identifying KNOX primary target genes and interactors of the KNOX/BELL complex.
An innovative application of Chromatin ImmunoPrecipitation (ChIP) modified for gene and protein discovery will be developed. This new approach will allow for the identification of KNOX target genes and new members of the KNOX/BELL complex.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences developmental biology
- medical and health sciences medical biotechnology cells technologies stem cells
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics nucleotides
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ROMA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.