Objective
The aim of this project is to understand how behaviours are controlled by neuronal circuits in zebrafish. Genetic methods such as the Gal4-UAS system will be used to express the light-gated cation channel channelrhodopsin-2 and the light-gated chloride pump halorhodopsin in defined neuronal populations. These optogenetic tools permit the stimulation (channelrhodopsin) or inhibition (halorhodopsin) of genetically targeted neurons by light in transparent zebrafish in vivo. Effects of these manipulations on behavior will be examined in forward and reverse behavioral screens. In forward experiments, swimming behaviors evoked by uniform or patterned stimulation of neurons will be analyzed in an unbiased manner. In reverse experiments, the effect of silencing defined populations of neurons will be evaluated in the context of an olfactory discrimination learning paradigm. The identification of defined neuronal populations involved in different behaviours will then serve as the starting point for the anatomical and functional analysis of the underlying circuits. The connectivity of the identified neuronal populations will be examined by anatomical methods and transsynaptic viral tracers. The function of neuronal circuits will be analyzed using 2-photon calcium imaging and electrophysiological methods. This integrated approach is expected to provide novel insights into the principles of information processing in the brain and establish a direct relationship between neuronal circuit function and behaviour.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- social sciences sociology social issues social inequalities
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
- natural sciences computer and information sciences data science data processing
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
4058 BASEL
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.