Objective
This Project aims at synthesising powerful chemical tools that make the neurotransmitter L-glutamate (L-Glu) detectable by fluorescence spectroscopy and permit to study its mobility, distribution and concentration in living cells with fluorescent microscopy, thus strongly contributing to the study of biologists and physiopathologists on neurological diseases in which this neurotransmitter seems to play an important role. L-Glu is the most abundant neurotransmitter of the excitatory synapses in the Central Nervous System (CNS). It is fundamental in the regulation and modulation of the CNS, in the regulation of the locomotive and physiological activity, in superior intellectual activity, and in affectivity and moods. Clinical studies have evidenced that metabolic damages of L-Glu are responsible of neurological and degenerative illnesses such as Parkinson, Alzheimer, Huntington, dementia, amyotrophic lateral sclerosis (ASL): in these pathologies L-Glu accumulates in extra-cellular space and becomes toxic for neurons. It is needed to investigate distribution and concentration of L-Glu directly in living cells but, the techniques available today, microdialyse and capillary electrophores, damage the living tissue. Fluorescence microscopy does not cause damages and provides sensitivity, selectivity and versatility but, L-Glu is not fluorescent by itself. In order to study it with fluorescent imaging techniques, we will synthesise chemical tools as: -a fluorescent L-Glu derivative: a synthetic molecule that can be inserted inside the cells and whose diffusion and distribution can be followed by imaging technique;-a fluorescent probe for L-Glu: selective receptors of L-Glu for determining distribution and concentration of L-Glu in extracellular space.The applicant, dr. Berni, and the Lacrem laboratory together can provide the multidisciplinary knowledge necessary to realise the Project: coordination chemistry, photo-physics, organic synthesis, analytical techniques.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences physical sciences optics microscopy
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine neurology parkinson
- medical and health sciences basic medicine neurology amyotrophic lateral sclerosis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PESSAC
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.