Objective
Stimulated Receptor Tyrosine Kinases (RTKs) regulate several key cellular processes, such as cell proliferation, differentiation, migration and transformation, by activating specific intracellular signaling pathways. Endocytosis, the process by which cells internalize and sort RTKs for either degradation or recycling, is a potent regulator of signal transduction specificity and cellular outcomes. Several RTKs have been shown to escape from the canonical degradative route under certain conditions, resulting in signaling amplification - which often results in tumorigenesis. In particular, EGFR and FGFRs follow opposite endocytic routes upon stimulation by different ligands. This application focuses on EGFR and FGFRs as model systems to define signaling cascades that are specifically regulated by the different endocytic pathways. We will integrate an unbiased data-driven approach consisting of quantitative proteomics, based on high-resolution mass-spectrometry in combination with proteome-wide metabolic incorporation of stable isotopes, followed by proper functional assays to validate the results. This system biology approach will shed light on some previously uncharacterized aspects of RTK signaling regulation at the whole-cell level, gaining insights into the molecular mechanisms underlying endocytosis-driven cellular responses. Since aberrant RTK signaling is a hallmark of various diseases, such as many cancers, the implications of our studies extend beyond basic research, offering the opportunity to identify novel therapeutic targets, e.g. for the development of anti-cancer drugs. These objectives are part of European research’s efforts to elucidate physiological processes, search for pathogenic events and novel targets and contribute to the technological progress of protein research.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology environmental engineering waste management waste treatment processes recycling
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.