Objective
Plasmodesmata are pores that interconnect plant cells and allow for the diffusion of small molecules as well as the selective intercellular trafficking of macromolecules. Recent research has shown them to be highly dynamic and regulated structures with en ormous influence on cell-cell communication and plant development as well as on both the systemic establishment of viral infections and the plant and aposs defense responses (RNA silencing).The plasmodesmal permeability for macromolecules can be altered by interaction with both plant-endogenous and viral proteins and it seems that some molecules, such as transcription factors, can be trafficked directionally and in a highly selective manner. The cellular machinery underlying macromolecular trafficking is so far poorly understood, due to the inaccessibility of plasmodesmata in the cell wall and the apparent lack of conserved trafficking signals in protein or RNA sequences. This project aims to identify novel proteins that are able to self-traffic between cell s, or have the ability to interact with, and dilate (gate), plasmodesmata.This will be achieved by using a novel viral vector-based transient expression system in combination with state-of-the-art live-cell-imaging techniques, together comprising a high-th roughput approach that will expand the range of tools available for postgenomic functional studies in plant molecular biology. Through the identification of new trafficking and gating proteins we expect to pin down some of the elusive components of the tra fficking machinery and the plasmodesmal pore itself. The results will form the basis of a mechanistic understanding of macromolecular trafficking and eventually lead to new applications in agronomically important areas such as the defense against viral cro p diseases and the manipulation of plant development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences molecular biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EDINBURGH
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.