Objective
Thrombosis is due to a combination of genetic and environmental factors. Activation of haemostasis, that constitutes the basis of thrombus formation, is the final step of a cascade of events in which genetic alterations can be determinant. Increase in inflammatory mediators has been implicated as a triggering factor.
Strategies focusing on the genetic analysis of measurable quantitative traits (QTL) that are correlated with disease risk are highly justified as compared to the previous emphasis on the analysis of the much less informative dichotomous disease traits. Because of their closer proximity to direct gene action, disease-related quantitative phenotypes represent one of the best chances to identify the underlying QTL that influence disease susceptibility.
It represents one of the more comprehensive approaches and provides important methodological challenges for its implementation both with regard to the genome scanning and the statistical and computational efforts that are required in order to adequately analyze the data produced. This approach works best when data can be collected on extended families. Unfortunately, family-based designs are still relatively rare in thrombosis/haemostasis studies.
The present project is aimed at identifying genes involved in the pathway: inflammation<->haemostasis->thrombus formation->myocardial infarction (MI). Data will come from large pedigrees selected from the general healthy population and through probands with MI before the age of 45, with at least another affected first degree relative with CVD before 65 years of age.
The project will profit of the combination of the broad experience of the host group in the field of genetic epidemiology, haemostasis, inflammation and cardiovascular risk factors with the experience of the applicant, who has been involved for several years in his country of origin in an international MedPed Familial Hypercholesterolemia Project dealing with families.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences health sciences public health epidemiology
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.