Objective
Blumeria graminis f. sp hordei is an economically important pathogen of cereals that causes barley powdery mildew. This obligate biotrophic pathogen is able to penetrate the cell wall barrier and develop a highly complex intracellular structure -the “haustorium”. This structure has long been known to actively take up nutrients, but it is now also believed to control host perception and defence, enabling the invading pathogen to survive, avoid and suppress rejection responses. How this is achieved is unknown, but current thinking postulates that this control is mediated by protein effectors secreted by the pathogen into the host cells. In this proposal I aim at discovering details of the molecular mechanisms by which B. graminis establishes control of the host barley cell through the action of the haustorium and effectors. To do this, I will define a panel of genes that encode candidate effectors proteins based on current data available and on new proteogenomic data generated at Dr. Spanu’s laboratory (Imperial College London, UK) in collaboration with the University of Reading (UK). These candidates will be cloned in vectors for functional analysis and expression as recombinant proteins. Effector proteins that alter infection levels will be identified by in vivo assays developed and used successfully by Dr. Wise’s group at USDA (USA). These effectors will be used to ‘’fish’’ host proteins they bind to and interact with, which will define candidate effectors targets. Evidence of interactions will be sough both, in the plant cells themselves and in extracts from infected plants. I will use the same approach to identify barley or Blumeria proteins which interact with Bln-1, the recently discovered modulator of susceptibility in Blumeria/barley interactions. Understanding of the molecular mechanisms underlying disease in the cereal mildew has the potential of aiding future developments in disease resistance and management.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
- agricultural sciences agriculture, forestry, and fisheries agriculture grains and oilseeds cereals
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SW7 2AZ London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.