Objective
Wolbachia is an intracellular bacterium capable of inducing various forms of the reproductive manipulation in a diversity of arthropods. The best characterized type of reproductive manipulation is cytoplasmic incompatibility (CI) which makes sperm from inf ected males unable to complete fertilization of eggs from uninfected females whereas eggs from infected females develop normally. At present the molecular basis for CI is not understood. Several genomes of CI-inducing Wolbachia are being sequenced and one of the most striking features is the high number of genes encoding ankyrin repeat (ANK) containing proteins found. This protein motif is common in eukaryotes where it has been shown to mediate protein-protein interaction, to interact with the cytoskeleton, to act as a transcription factor and to modify the activity of cell-cycle regulating proteins. Since CI appears to involve disruption of host cell-cycle timing, the ANK genes represent promising candidates for control of the phenotype. The project aims to understand the role of the ANK genes in CI by looking at the variability and expression, potential interactions with other proteins and localization of the ankyrins in relevant tissues.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences medical biotechnology genetic engineering gene therapy
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences zoology invertebrate zoology
- natural sciences biological sciences genetics genomes prokaryotic genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OXFORD
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.