Objective
Neurotransmission in dopamine systems of the brain has a central role in controlling a number of functions, including movement, as well as reward and reinforcement for both natural rewards and those associated with addictive drugs.
There is increasing evidence that neurotransmitters in addition to DA are involved, and that their dysregulation contributes to disorders associated with movement and influences the maintenance of craving and the susceptibility to re-use drugs.
Thus, the cortico-striatal glutamate pathway has been implicated considering its association with DA in the striatum. Cholecystokinin (CCK) may also be involved. CCK is a likely co-transmitter in the cortico-striatal glutamate pathway and is also present in DA neurons that innervate limbic regions of the striatum.
While the focus of CCK studies have been its cortical input onto the dorsal striatum and its association with movement, questions regarding the CCK innervation of the ventral striatum remain to be clarified, as do functional aspect s of CCK receptors in cellular signalling mechanisms in the brain.
This project will provide anatomical and histochemical evidence for CCK cortical projections to the ventral striatum, and with in vivo microdialysis will biochemically examine the role of C CK in the limbic system. Effects of CCK on behaviour, with respect to reward, addiction and motor control, after pharmacological modulation and/or genetic deletion of CCK receptors, will also be examined.
Finally, molecular techniques, including gene gun transfer and calcium imaging in organotypic cultures will be implemented to investigate functional properties of CCK receptors in striatal neurons, and to study their relationship with G-proteins and DA and NMDA receptors.
Characterisation of the influence of CCK in limbic regions of the brain may provide possibilities for new experimental, conceptual and therapeutic approaches to control reward, addiction, panic disorders, anxiety and possibly schizophrenia.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- medical and health sciences basic medicine neurology parkinson
- medical and health sciences clinical medicine psychiatry schizophrenia
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.