Objective
Type 2 diabetes is one of the most common chronic diseases in the world, and the number of those affected has been raising dramatically in recent years. In type 2 diabetes the body fails to use insulin effectively, which leads to the chronic increase in blood glucose that characterises the disease. It is not known why the body becomes resistant to insulin but evidence suggests that an imbalance between energy intake, storage, and expenditure can lead to obesity and insulin resistance. Thus, to understand the origins of diabetes it is fundamental to understand how the organism evaluates and controls its metabolic requirements. The hypothalamus in the base of the brain is essential for orchestrating such functions, aided by specific cell groups which detect changes in extracellular levels of nutrients. I suggest that a disruption in these sensing mechanisms in the hypothalamus can lead to a metabolic imbalance in the body. In this project I will study the properties of hypothalamic nutrient-sensing neurones in a model of obesity and insulin resistance. A novel approach that will combine state-of-the-art cell physiology, biochemistry, cellular and mitochondrial bioenergetics, and molecular imaging methods in a multidisciplinary environment will be key to unravel some of the mechanisms used by nutrient-sensing neurones in health and disease. This project will thus provide a better understanding of the role of these mechanisms in obesity, insulin resistance, and diabetes. That knowledge will potentially open new avenues to the development of novel strategies for treating metabolic diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine physiology
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2 DUBLIN
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.