Objective
Chronic renal failure is characterized by its progressive loss of kidney functions, without therapeutic possibilities. One of the main factors that entail chronic renal failure is glomerular hypertension, which is responsible for the loss or the damage of a highly-specialized epithelial cells of the glomerulus, the podocyte.
Podocytes covering the outer aspect of glomerular capillaries and perform interdigitations by their foot processes forming the filter barrier in kidney. The organization of the actin cytoskeleton of podocytes plays a critical role on the permeability of the glomerular filtration barrier. Previous studies of the host laboratory have shown that podocytes are mechano-sensitive.
Mechanical stress induces a reversible reorganization of the actin cytoskeleton, accompanied by a change of the gene expression pattern. Gene array analysis allowed the identification of an important matricellular protein, osteopontin (OPN), which is strongly up-regulated by mechanical stress. OPN enhances adaptation of podocytes to mechanical stress by reorganization of the actin cytoskeleton.
The aim of the project is to identify the binding domain of OPN, the OPN receptor, and the signalling cascade activated by OPN in podocytes that mediate mechano-protection. Elucidation of the mechano-protective signalling pathway of OPN in podocytes will provide the basis for the rational design of therapeutics that could mimic the mechano-protective action of OPN.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.