Objective
Podocytes are injured in many forms of human and experimental glomerular disease such as focal segmental glomelurosclerosis, diabetic nephropathy, and crescentic glomerulonephritis. The singularity of the actin cytoskeleton in podocytes and its critical role for podocyte function is well known.
Indeed, podocytes express unique actin-associated proteins such as synaptopodin, mutation or absence of alfa-actinin-4 result in glomerulosclerosis due to podocyte loss by unknown reasons, and several stimuli like polycations and mechanical stress are known to induce rapid and profound reorganization of the actin cytoskeleton in podocytes.
Since it was shown that palladin is expressed and localized to various actin structures in podocytes, that palladin induces and is required for stress fiber formation, and that palladin is known to interact with several proteins expressed in podocytes (alfa-actinin, VASP and ezrin), it seems that palladin plays an important role for the organization of the actin cytoskeleton in podocytes.
Elucidation of the role of palladin and its binding partners in podocytes as well as elucidation of its implication in renal disease will provide new insights into glomerular diseases and new perspectives in therapeutics.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine endocrinology diabetes diabetic nephropathy
- medical and health sciences clinical medicine nephrology kidney diseases
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
GREIFSWALD
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.