Objective
Megalin and cubilin mediated endocytosis at the apical pole of proximal tubule epithelial cells constitute a major route for renal retrieval of several essential glomerular filtrate solutes such as proteins vitamins and calcium. Pathophysiological signific ance of these receptors is supported by the finding of low-molecular weight proteinuria in megalin knockout mice and in dogs that bear inherited disorder of cubilin intracellular trafficking although the structure of cubilin is normal. Recently two protein s possibly responsible for cubilin trafficking has been identified: amnionless and cubilin-binding protein. The aim of the study is a closer characterization of those proteins and their role in megalin/cubilin mediated endocytosis as well as disclosure of possible target molecules/interactions for pharmacological intervention preventing reabsorption of toxic molecules in the proximal tubule. The studies include identification of the proteins involved, their purification and analysis, characterization of the ir interactions and subcellular distribution as well as functional studies by molecular biology approaches and pharmacological targeting. The intimate knowledge of the molecular interactions involved in the endocytic process that will be gained from the pr esent study are essential for the development of new therapeutic approaches in nephrology that involve modulation of cubilin and megalin expression/function in order to prevent or attenuate tubular uptake of deleterious substances. The project is the furth er initiative of the applicant in his scientific training, which started in Department of Biochemistry in Poland and was followed by stay in the Department of Cell Biology in Denmark. During the stay in INSERM U538 (Membrane Traffic in Epithelial Cells) th e applicant will be provided with thorough training in cell culture and molecular biology techniques.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine nephrology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pathology
- medical and health sciences clinical medicine transplantation
- natural sciences biological sciences molecular biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.