Objective FLUPIG aims at a better understanding of the role of pigs in influenza pandemics. Pandemic influenza viruses come from wild birds, but they must adapt to efficient replication and transmission in humans to cause a pandemic. Pigs are considered important intermediate hosts in which avian viruses adapt to mammals before they transmit to humans. However, the exact role of pigs is unclear, as is the nature of the genetic changes that are required for (a) efficient replication of an avian virus in pigs, (b) efficient transmission of avian viruses between pigs and (c) virus transmission from pigs to humans and between humans. The FLUPIG consortium will examine both the role of adaptive mutations and genetic reassortment. In addition, we will study the role of host and environmental factors in adaptation of avian influenza viruses to pigs. The occurrence and severity of a pandemic also depends on the immune status of the human population. The FLUPIG consortium will study the extent of cross-protection between antigenically different influenza viruses of the H1N1 subtype (heterovariant cross-protection), and between influenza viruses belonging to different haemagglutinin subtypes (heterosubtypic cross-protection). We will also study the immune mechanisms required for a broad cross-protection. In addition, we will evaluate the capacity of novel generation vaccines to broaden cross-protection. Most studies will be performed in pigs or other relevant animals, or in explants of the porcine and human respiratory tract, which show maximal similarity to the in vivo situation. Our studies will enable us to advice public health authorities about the role and risk of the pig in the emergence of novel influenza viruses in the human population. Combined with improved surveillance for influenza in animals, effective vaccines and antivirals, this knowledge will be critical to the control of future influenza pandemics. Fields of science natural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencespublic healthepidemiologypandemicsmedical and health scienceshealth sciencesinfectious diseasesRNA virusesinfluenzamedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantivirals Programme(s) FP7-KBBE - Specific Programme "Cooperation": Food, Agriculture and Biotechnology Topic(s) KBBE.2010.1.3-06 - Pathogenesis and transmission of influenza in pigs Call for proposal FP7-INFLUENZA-2010 See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator UNIVERSITEIT GENT Address Sint pietersnieuwstraat 25 9000 Gent Belgium See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Higher or Secondary Education Establishments Administrative Contact Karen Van Der Meulen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 1 005 499,00 Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLE VENEZIE Italy EU contribution € 400 000,00 Address Viale dell universita 10 35020 Legnaro See on map Region Nord-Est Veneto Padova Activity type Other Administrative Contact Ilaria Capua (Dr.) Links Contact the organisation Opens in new window Website Opens in new window IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE United Kingdom EU contribution € 353 063,00 Address South kensington campus exhibition road SW7 2AZ London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Tatjana Palalic (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Food and Environment Research Agency United Kingdom EU contribution € 500 000,00 Address Area 1a, nobel house, smith square 17 SW1P 3JR London See on map Region London Inner London — West Camden and City of London Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Lucinda Cranham (Ms.) Links Contact the organisation Opens in new window Website Opens in new window PHILIPPS UNIVERSITAET MARBURG Germany EU contribution € 375 000,00 Address Biegenstrasse 10 35037 Marburg See on map Region Hessen Gießen Marburg-Biedenkopf Activity type Higher or Secondary Education Establishments Administrative Contact Christian Veldman (Dr.) Links Contact the organisation Opens in new window Website Opens in new window ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands EU contribution € 500 800,00 Address Dr molewaterplein 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Administrative Contact Wim Leep (Mr.) Links Contact the organisation Opens in new window Website Opens in new window PANSTWOWY INSTYTUT WETERYNARYJNY - PANSTWOWY INSTYTUT BADAWCZY Poland EU contribution € 324 960,00 Address Partyzantow 57 24100 Pulawy See on map Region Makroregion wschodni Lubelskie Lubelski Activity type Research Organisations Administrative Contact Iwona Markowska - Daniel (Prof.) Links Contact the organisation Opens in new window Website Opens in new window HKU - Pasteur Research Centre Limited Hong Kong EU contribution € 375 150,00 Address 1-3/f dexter h.c. man building sassoon road 8 HKG Pokfulam hong kong See on map Activity type Research Organisations Administrative Contact Malik Peiris (Prof.) Links Contact the organisation Opens in new window KANSAS STATE UNIVERSITY United States EU contribution € 499 980,00 Address Fairchild hall 2 66506-1103 Manhattan ks See on map Activity type Higher or Secondary Education Establishments Administrative Contact Paul Lowe (Mr.) Links Contact the organisation Opens in new window Website Opens in new window FRIEDRICH LOEFFLER INSTITUT - BUNDESFORSCHUNGSINSTITUT FUER TIERGESUNDHEIT Germany EU contribution € 520 000,00 Address Sudufer 10 17493 Greifswald-insel riems See on map Region Mecklenburg-Vorpommern Mecklenburg-Vorpommern Vorpommern-Greifswald Activity type Research Organisations Administrative Contact Thomas C. Mettenleiter (Prof.) Links Contact the organisation Opens in new window Website Opens in new window
