Objective Cancer is a complex disease involving multiple genetic and epigenetic events occurring, and influencing each other, over a long period of time. Understanding cancer, and ultimately developing effective targeted therapies, will therefore require that mutations and epigenetic alterations be systematically investigated during the multiple stages of disease development, from identifiable pre-neoplastic phases to overt cancer. Until now, no systematic effort has been undertaken to investigate these multiple layers of genome organization and function during cancer development. MODHEP aims at providing a 360° understanding of liver cancer, one of the most common types of tumors and, because of the homogeneity of the hepatic tissue, the most experimentally tractable one. The consortium brings together elite European scientists in the fields of genetics, chromatin regulation, genomics, liver cancer, computational and systems biology. This combination of skills will allow us to investigate and model at unprecedented resolution the chain of events leading from environmental perturbations and the occurrence of driver mutations to preneoplastic disease and cancer. Our experimental plan reflects some grounded assumptions: 1. cancer cannot be modeled without detailed information on the preneoplastic stages of disease; 2. genetic heterogeneity in humans would make systems-level modeling non realistic from a practical point of view. Both of these limitations are bypassed by the use of well-defined mouse models, followed by evaluation of the main conclusions in clinical samples; 3. many early stage driving events in cancer represent epigenetic alterations, which are invisible to classical genetic analysis, and are confounded by secondary and tertiary events in established tumors. Our approach will enable the identification of therapeutically relevant early-stage genetic and epigenetic alterations and the definition of their interplay in tumor development and maintenance. Fields of science medical and health sciencesclinical medicineoncologyliver cancernatural sciencesbiological sciencesgeneticsmutationnatural sciencesbiological sciencesgeneticsgenomesnatural sciencesbiological sciencesgeneticsepigenetics Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.2.1.2-1 - Tackling Human Diseases through Systems Biology Approaches. FP7-HEALTH-2010-two-stage Call for proposal FP7-HEALTH-2010-two-stage See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Address Via morego 30 16163 Genova Italy See on map Region Nord-Ovest Liguria Genova Activity type Research Organisations Administrative Contact Giulia Campodonico (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 687 841,70 Participants (17) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT CURIE France EU contribution € 1 362 500,00 Address Rue d ulm 26 75231 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Corinne Cumin (Ms.) Links Contact the organisation Opens in new window Website Opens in new window MEDICAL RESEARCH COUNCIL United Kingdom EU contribution € 11 903,99 Address 20 park crescent W1B 1AL London See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Kate Wilson (Dr.) Links Contact the organisation Opens in new window Website Opens in new window KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW Netherlands EU contribution € 805 000,00 Address Kloveniersburgwal 29 het trippenhuis 1011 JV Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Other Administrative Contact Don Van Velzen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window FONDAZIONE TELETHON ETS Italy EU contribution € 825 230,99 Address Via varese 16/b 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Administrative Contact Irene Mearelli (Dr.) Links Contact the organisation Opens in new window Website Opens in new window THE UNIVERSITY OF EDINBURGH United Kingdom EU contribution € 493 177,00 Address Old college, south bridge EH8 9YL Edinburgh See on map Region Scotland Eastern Scotland Edinburgh Activity type Higher or Secondary Education Establishments Administrative Contact Isobel Blair (Ms.) Links Contact the organisation Opens in new window Website Opens in new window THE BABRAHAM INSTITUTE United Kingdom EU contribution € 797 486,00 Address Babraham hall CB22 3AT Cambridge See on map Region East of England East Anglia Cambridgeshire CC Administrative Contact Caroline Edmonds (Dr.) Links Contact the organisation Opens in new window Website Opens in new window WEIZMANN INSTITUTE OF SCIENCE Israel EU contribution € 647 999,00 Address Herzl street 234 7610001 Rehovot See on map Activity type Higher or Secondary Education Establishments Administrative Contact Talia Tzahor (Ms.) Links Contact the organisation Opens in new window Website Opens in new window RIKEN THE INSTITUTE OF PHYSICAL ANDCHEMICAL RESEARCH Japan EU contribution € 951 000,00 Address Hirosawa 2-1 351 0198 Wako shi saitama See on map Administrative Contact Haruo Yamaguchi (Mr.) Links Contact the organisation Opens in new window INSTITUT PASTEUR France EU contribution € 800 000,00 Address Rue du docteur roux 25-28 75724 Paris See on map Region Ile-de-France Ile-de-France Paris Administrative Contact Nadia Khelef (Dr.) Links Contact the organisation Opens in new window Website Opens in new window INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 760 004,00 Address Rue de tolbiac 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Administrative Contact Annick Salini (Ms.) Links Contact the organisation Opens in new window Website Opens in new window BIOBYTE SOLUTIONS GMBH Germany EU contribution € 318 600,00 Address Bothestrasse 142 69126 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ivica Letunic (Dr.) Links Contact the organisation Opens in new window Website Opens in new window ACIES Consulting Group SAS France EU contribution € 295 569,99 Address Rue de la république 69 69002 Lyon See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Elise Castan (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window NOVAMEN SAS Participation ended France EU contribution € 167 210,01 Address Rue de la république 69 69002 Lyon See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Elise Castan (Mrs.) Links Contact the organisation Opens in new window MATER MEDICAL RESEARCH INSTITUTE LIMITED Australia EU contribution € 577 570,00 Address Level 3 aubigny place South brisbane See on map Activity type Research Organisations Administrative Contact Ian Allan (Mr.) Links Contact the organisation Opens in new window Website Opens in new window FONDAZIONE SANTA LUCIA Italy EU contribution € 574 148,00 Address Via ardeatina 306 00179 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Administrative Contact Antonio Lerna (Dr.) Links Contact the organisation Opens in new window Website Opens in new window ISTITUTO EUROPEO DI ONCOLOGIA SRL Italy EU contribution € 1 762 573,32 Address Via filodrammatici 10 20121 Milano See on map Region Nord-Ovest Lombardia Milano Administrative Contact Ilaria Foti (Ms.) Links Contact the organisation Opens in new window Website Opens in new window KING'S COLLEGE LONDON United Kingdom EU contribution € 99 085,00 Address Strand WC2R 2LS London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Paul Labbett (Mr.) Links Contact the organisation Opens in new window Website Opens in new window
