Objective Hepatocellular carcinoma (HCC) accounts for more than 90% of liver cancers, and is a major health problem. Its incidence is growing and with more than 700,000 annual cases worldwide -50,000 in Europe-, it is the 3rd cause of cancer-related mortality. Most patients are diagnosed at advanced stages with dismal survival rates lower than 1 year, even after sorafenib, the sole systemic therapy available. The main goal of the HEPTROMIC project is to produce breakthrough knowledge in two critical aspects of HCC research: prognostic prediction and identification of oncogenic drivers susceptible for intervention, leading towards more personalized treatment algorithms. The HEPTROMIC Consortium proposes a 3-year translational research study bringing together an outstanding team of researchers with clinical and genomic expertise along with cutting-edge technology. Eight partners -six academic and two SMEs- will address the following objectives by applying high-end transcriptome, methylome and deep sequencing technology in a large set of 1,140 human samples: Objective 1) Genomic characterization of poor prognosis subclass of hepatocellular carcinoma. Objective 2) Identification of driver oncogenic events as potential treatment targets. Findings obtained will be confirmed in sophisticated experimental models that closely mimics human liver cancer. Objective 3) Design of prognostic devices for clinical translation. This transfer of knowledge will be led by SMEs with entrepreneurial management skills with experience in creating new products increasing European competitiveness and boosting the innovative capacity of industries. Overall, the Consortium foresees impacts on improved patient survival by refining prognosis and decision-making, identifying targets amenable for selective therapies and by improving the allocation of resources. In summary, HEPTROMIC will strength links between the academic and industry spheres, ultimately contributing to reduce liver cancer mortality. Fields of science natural sciencesbiological sciencesgeneticsmedical and health sciencesclinical medicineoncologyliver cancersocial sciencessociologydemographymortality Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.2.4.1-6 - Translational research on cancers with poor prognosis. FP7-HEALTH-2010-two-stage Call for proposal FP7-HEALTH-2010-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Address Calle rossello 149 puerta bjs 08036 Barcelona Spain See on map Region Este Cataluña Barcelona Activity type Other Administrative Contact Pastora Martinez Samper (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 708 088,00 Address Rue de tolbiac 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Jamil Slaoui (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE Spain EU contribution € 336 130,00 Address Avenida gran via hospitalet 199-203 08908 L'hospitalet de llobregat See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact Carole Amroune (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH Participation ended Germany EU contribution € 125 957,44 Address Inhoffenstrasse 7 38124 Braunschweig See on map Region Niedersachsen Braunschweig Braunschweig, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Michael Straetz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI Italy EU contribution € 152 400,00 Address Via venezian 1 20133 Milan See on map Region Nord-Ovest Lombardia Milano Activity type Research Organisations Administrative Contact Antonio Cannarozzo (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE BROAD INSTITUTE INC CORPORATION*BROAD INSTITUTE OF MIT AND HARVARD Participation ended United States EU contribution € 124 148,44 Address Cambridge center 7 02142 Cambridge See on map Activity type Research Organisations Administrative Contact Jennifer Hyne (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data DIAGENODE Belgium EU contribution € 275 235,00 Address Rue du bois saint jean 3 liege park science 4102 Seraing See on map Region Région wallonne Prov. Liège Arr. Liège Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Léon Etienne (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data FIRALIS MOLECULAR PRECISION SA France EU contribution € 241 888,00 Address 17 rue du fort 68330 Huningue See on map Region Grand Est Alsace Haut-Rhin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Philippe Jaffré (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data EBERHARD KARLS UNIVERSITAET TUEBINGEN Germany EU contribution € 195 191,36 Address Geschwister-scholl-platz 72074 Tuebingen See on map Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Higher or Secondary Education Establishments Administrative Contact Lars Zender (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI United States EU contribution € 43 538,42 Address One gustave l levy place box 1075 10029 6574 New york See on map Activity type Higher or Secondary Education Establishments Administrative Contact Christiina Lin (Ms.) Links Contact the organisation Opens in new window Other funding No data
