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Immunogenomics: Mouse to Human Translational Research

Objective

Control over the activation of the immune system is central to the key issues of human health. Autoimmunity, atopy, persistent infections and tumours all share a common root cause in a sub-optimal balance between immune activity and tolerance. At the heart of this balance are T cells, with the capacity for both activation and suppression. Research in mouse models has allowed enormous progress to be made on understanding fundamental mechanics, and yet the next step translating this understanding into therapeutics has proven far more difficult than originally anticipated. The basis of this problem may be a reliance on the mouse model without parallel human research. In this project we propose to create a dynamic interplay between the technological advantages of working in mouse models and the physiological relevance of studying the human immune system in three key research areas.

The first research track is a gene discovery program, using an immunology-orientated approach to allow the discovery of important human disease genes that remain invisible to clinically-orientated approaches. The second research track is a functional genomics program, seeking to address the mechanistic questions that arise from traditional disease-gene association studies. This information is of critical importance in translating genetic data into therapeutic interventions and provides the basis for personalised medicine. The third research track is a direct hypothesis-driven project testing the role that genetic variation in the target organ alters susceptibility to autoimmune disease. Each of these research tracks utilises cutting edge technology in genetics and immunology, combining knowledge from mouse models with innovative study design in human populations.

Field of science

  • /medical and health sciences/basic medicine/immunology/autoimmune diseases

Call for proposal

ERC-2010-StG_20091118
See other projects for this call

Funding Scheme

ERC-SG - ERC Starting Grant

Host institution

VIB VZW
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Belgium
Activity type
Research Organisations
EU contribution
€ 1 496 687,87
Principal investigator
Adrian Liston (Prof.)
Administrative Contact
Rik Audenaert (Mr.)

Beneficiaries (1)

VIB VZW
Belgium
EU contribution
€ 1 496 687,87
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
Principal investigator
Adrian Liston (Prof.)
Administrative Contact
Rik Audenaert (Mr.)